Plasma dehydroepiandrosterone in pregnant and nonpregnant women.
Plasma dehydroepiandrosterone in pregnant and nonpregnant women.
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孕妇和非孕妇的血浆脱氢表雄酮。
DOI：
10.1016/0009-8981(75)90356-3
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
T. Walk
中科院分区：
文献类型：
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作者：
A. Schindler;K. Gnad;T. Walk
用Amberlite XAD-2型柱层析、酶解、放射性内标、薄层层析和三甲基硅烷醚衍生物形成后的气-液色谱，在45°C下，对15 7例正常妊娠妇女和42例非妊娠妇女的血浆总脱氢表雄酮进行了测定。结果表明：非妊娠个体血浆脱氢表雄酮含量为(n=2 5)69.6±10.6μg/100ml，非妊娠样品(n=17)脱氢表雄酮含量为(n=17)67.7μg/10 0ml；个体样本妊娠6-12周(n=32)48.5±5.7μg/100ml(S.E.M.)，个体样本13-18周(n=13)45.9±7.7μg/100ml(S.E.M.)，个体样本19-24周(n=20)42.9±6.9μg/100ml(S.E.M.)；个体样本妊娠25-30周(n=22)41.7±6.8μg/100ml(S.E.M.)，妊娠31-36周(n=31)39.5±6.1μg/100ml(S.E.M.)，妊娠37-43周(n=29)37.6±3.6μg/100ml(S.E.M.)；10例妊娠37-43周孕妇血浆总脱氢表雄酮浓度为25.4μg/100ml。本研究证实，在正常妊娠过程中，个体和混合血浆样本中总脱氢表雄酮显著下降，从而证实了先前的报道。这些血浆激素的变化与妊娠期间这种类固醇的产生和利用有关。
From 157 plasma samples taken randomly throughout normal pregnancy and from 42 plasma samples of nonpregnant women, total plasma dehydro-epiandrosterone was measured by a method using Amberlite XAD-2 column chromatography at 45°C, enzyme hydrolysis, radioactive internal standard, thin-layer chromatography and gas-liquid chromatography after trimethylsilyl ether derivative formation.The following values for dehydroepiandrosterone were obtained: from individual, nonpregnant samples, (n= 25) 69.6 ± 10.6 μg/100 ml (S.E.M.); from the pool of nonpregnant samples (n= 17) 67.7 μg/100 ml; from individual samples, 6–12 weeks of gestation (n= 32) 48.5 ± 5.7 μg/100 ml (S.E.M.); from individual samples, 13–18 weeks of gestation (n= 13) 45.9 ± 7.7 μg/100 ml (S.E.M.); from individual samples, 19–24 weeks of gestation (n= 20) 42.9 ± 6.9 μg/100 ml (S.E.M.); from individual samples, 25–30 weeks of gestation (n= 22) 41.7 ± 6.8 μg/100 ml (S.E.M.); from individual samples, 31–36 weeks of gestation (n= 31) 39.5 ± 6.1 μg/100 ml (S.E.M.); from individual samples, 37–43 weeks of gestation (n= 29) 37.6 ± 3.6 μg/100 ml (S.E.M.); and from the pool sample, 37–43 weeks of gestation (n= 10) 25.4 μg/100 ml.This study demonstrates a significant decrease of total plasma dehydroepiandrosterone throughout the course of normal pregnancy in individual and pooled plasma samples, thus confirming previous reports. These plasma hormone changes are discussed in relation to production and utilization of this steroid in pregnancy.