Decreased frontal white-matter integrity in abstinent methamphetamine abusers
Decreased frontal white-matter integrity in abstinent methamphetamine abusers
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DOI：
10.1017/sl461145706007395
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发表时间：
2007-12-01
影响因子：
4.8
通讯作者：
Renshaw, Perry F.
中科院分区：
文献类型：
--
作者：
Chung, Ain;Lyoo, In Kyoon;Renshaw, Perry F.
本研究采用扩散张量成像（DTI）技术探讨了甲基苯丙胺（MA）滥用者和健康对照者额叶白质（WM）完整性的差异。分数各向异性（FA）值，这表明WM的完整性，计算的利益区域在额叶WM扩散张量图像的32 MA滥用者和30名健康对照组。额叶执行功能也通过威斯康星州卡片分类测试（WCST）进行评估。与健康对照受试者相比，MA滥用者在前连合-后连合（AC-PC）平面的双侧额叶WM和AC-PC平面上方5 mm的右侧额叶WM的FA值显著较低。MA滥用者有更多的总，持续和非持续错误的WCST相对于健康的对照组。MA滥用者WCST总错误数和非持续错误数与AC PC平面上方5 mm处的右额叶WM FA值呈负相关。在性别差异的子分析中，仅在男性滥用者中发现额叶WM的FA值较低，WCST的错误较多，而女性滥用者中没有发现。我们报告说，正面WM的完整性MA滥用者受到损害。这一发现也可能与额叶执行功能受损有关。此外，MA对额叶WM的神经毒性作用在女性中可能不如男性突出，这可能是由于雌激素的神经保护作用。
This study explored differences in frontal white-matter (WM) integrity between methamphetamine (MA) abusers and healthy comparison subjects using diffusion tenser imaging (DTI). Fractional anisotropy (FA) values, which indicate WM integrity, were calculated for regions-of-interest in frontal WM on diffusion tensor images of 32 MA abusers and 30 healthy comparison subjects. Frontal executive functions were also assessed by the Wisconsin Card Sorting test (WCST). MA abusers had significantly lower FA values in bilateral frontal WM at the anterior commissure-posterior commissure (AC-PC) plane and the right frontal WM 5 mm above the AC-PC plane relative to healthy comparison subjects. MA abusers had more total, perseveration and non-perseveration errors in the WCST relative to healthy comparison subjects. FA values of the right frontal WM 5 mm above the AC-PC plane negatively correlated with the number of total and non-perseveration errors in the WCST in MA abusers. In the sub-analysis for gender differences, lower FA values in frontal WM and more errors in the WCST were found only in male MA abusers, not in female MA abusers, relative to comparison subjects of the respective gender. We report that frontal WM integrity of MA abusers is compromised. This finding may also be related to impairment in frontal executive function. In addition, the neurotoxic effect of MA on frontal WM may be less prominent in women than in men, possibly due to oestrogen's neuroprotective effect.