Maximum slope of ultrafast dynamic contrast-enhanced MRI of the breast: Comparisons with prognostic factors of breast cancer
Maximum slope of ultrafast dynamic contrast-enhanced MRI of the breast: Comparisons with prognostic factors of breast cancer
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DOI：
10.1007/s11604-020-01049-6
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发表时间：
2020-10
影响因子：
2.1
通讯作者：
K. Yamaguchi;T. Nakazono;R. Egashira;Shuichi Fukui;K. Baba;T. Hamamoto;H. Irie
中科院分区：
文献类型：
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作者：
K. Yamaguchi;T. Nakazono;R. Egashira;Shuichi Fukui;K. Baba;T. Hamamoto;H. Irie
目的探讨超快动态增强MRI（ultrafast dynamic contrast-enhanced，DCE）最大斜率（maximum slope，MS）与乳腺癌预后因素的关系。使用更高的并行成像因子获取超快DCE序列。其空间分辨率为0.9 × 0.9 × 2.5mm，时间分辨率为8.3s/相。每个病变被自动分割，并确定病变中最高增强的ROI。在该ROI中，计算MS。每个病灶的MS进行了比较与各种预后因素的乳腺cancer.ResultsThe MS的浸润性癌（中位数：9.81%/秒）是显着高于导管原位癌（中位数：7.26%/秒）（P= 0.001）。在ROC分析中，ROC曲线下面积（AUC）为0.7295。浸润性癌伴腋淋巴结（LN）转移（中位数：11.97%/sec）的MS显著高于无腋淋巴结转移（中位数：9.425%/sec）（p= 0.0024）。在ROC分析中，AUC为0.7177。此外，MS成为显着更高的增殖标志物ki-67的水平增加（相关系数：0.3317）（p= 0.0009）。结论MS的超快DCE-MRI是有用的预测乳腺癌的预后factors of breast cancer.Secondary abstractHigher maximum slope（MS）is significantly associated with a invasive breast cancer component。较高的MS与腋窝淋巴结转移显著相关。随着ki-67（增殖标记物）的增加，MS显着升高。超快MRI对预测乳腺癌的预后有一定的价值。
PurposeTo determine the relationship between the maximum slope (MS) of ultrafast dynamic contrast-enhanced (DCE)-MRI and prognostic factors of breast cancer.MethodsOne hundred thirteen patients with 118 breast cancers were included in this study. The ultrafast DCE sequence was acquired using a higher parallel imaging factor. Its spatial resolution was 0.9 × 0.9 × 2.5 mm and its temporal resolution was 8.3 s/phase. Each lesion was automatically segmented, and the ROI of highest enhancement in the lesion was identified. In this ROI, the MS was calculated. The MS of each lesion was compared with various prognostic factors of breast cancer.ResultsThe MS of invasive cancer (median: 9.81%/sec) was significantly higher than that of ductal carcinoma in situ (median: 7.26%/sec) (p= 0.001). In the ROC analysis, the area under the ROC curve (AUC) was 0.7295. The MS of invasive cancer with axillary lymph node (LN) metastasis (median: 11.97%/sec) was significantly higher than that without axillary LN metastasis (median: 9.425%/sec) (p= 0.0024). In the ROC analysis, the AUC was 0.7177. In addition, the MS became significantly higher as the level of the proliferation marker ki-67 increased (correlation coefficient: 0.3317) (p= 0.0009).ConclusionsMS of ultrafast DCE-MRI is useful for predicting the prognostic factors of breast cancer.Secondary abstractHigher maximum slope (MS) is significantly associated with an invasive breast cancer component. Higher MS is significantly associated with an axillary lymph node metastasis. MS becomes significantly higher with increasing ki-67 (a proliferation marker). Ultrafast MRI is useful for predicting the prognostic factors of breast cancer.