Synthesis and biological activity of 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles.
Synthesis and biological activity of 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles.
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DOI：
10.1016/j.bmcl.2009.07.139
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发表时间：
2009-10
影响因子：
2.7
通讯作者：
Kristin A. Milinkevich;C. Yoo;T. C. Sparks;B. Lorsbach;M. Kurth
中科院分区：
文献类型：
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作者：
Kristin A. Milinkevich;C. Yoo;T. C. Sparks;B. Lorsbach;M. Kurth
Acid hydrazides were coupled with acrylic acid derivatives and cyclodehydration gave 1,3,4-oxadiazoles. Lastly, in-situ nitrile oxide formation from aryl oximes treated with sodium hypochlorite, and subsequent 1,3-dipolar cycloaddition to the exomethylene moiety delivered 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles. This library was evaluated in a high-throughput screen at Dow AgroSciences. Several compounds were active against fungal pathogens and pest insects.
