Multivariate Analysis of Vocal Fold Vibrations on Various Voice Disorders Using High-Speed Digital Imaging
Multivariate Analysis of Vocal Fold Vibrations on Various Voice Disorders Using High-Speed Digital Imaging
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DOI：
10.3390/app11146284
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发表时间：
2021-07-01
影响因子：
2.7
通讯作者：
Tayama, Niro
中科院分区：
文献类型：
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作者：
Yamauchi, Akihito;Imagawa, Hiroshi;Tayama, Niro
虽然已经设计了许多定量参数来描述声带振动异常，但对这些参数的优先级知之甚少。我们进行了一项前瞻性研究，使用高速数字成像来阐明疾病特异性关键参数（KPs），以表征个体嗓音疾病的声带振动。从304例患者的各种语音障碍和46个正常的扬声器，高速数字成像的持续发声在一个舒适的音调和响度记录和参数的视觉感知等级，喉地形图，数字记波图，声门面积波形进行了计算。然后，对这些参数进行多变量分析，以阐明与正常受试者相比，KPs来解释每种嗓音障碍。四个关键参数对所有喉部疾病均有统计学意义。然而，决定系数（R-2）非常低（0.29）。声带麻痹（8个KP，R-2 = 0.76）、声带沟（4个KP，R-2 = 0.74）、声带瘢痕（1个KP，R-2 = 0.68）、声带萎缩（6个KP，R-2 = 0.53）和喉癌（1个KP，R-2 = 0.52）显示出中等至高的R-2值。结果为每种嗓音障碍确定了不同的KP;因此，疾病特异性分析是一种合理的方法。
Although many quantitative parameters have been devised to describe abnormalities in vocal fold vibration, little is known about the priority of these parameters. We conducted a prospective study using high-speed digital imaging to elucidate disease-specific key parameters (KPs) to characterize the vocal fold vibrations of individual voice disorders. From 304 patients with various voice disorders and 46 normal speakers, high-speed digital imaging of a sustained phonation at a comfortable pitch and loudness was recorded and parameters from visual-perceptual rating, laryngotopography, digital kymography, and glottal area waveform were calculated. Multivariate analysis was then applied to these parameters to elucidate the KPs to explain each voice disorder in comparison to normal subjects. Four key parameters were statistically significant for all laryngeal diseases. However, the coefficient of determination (R-2) was very low (0.29). Vocal fold paralysis (8 KPs, R-2 = 0.76), sulcus vocalis (4 KPs, R-2 = 0.74), vocal fold scarring (1 KP, R-2 = 0.68), vocal fold atrophy (6 KPs, R-2 = 0.53), and laryngeal cancer (1 KP, R-2 = 0.52) showed moderate-to-high R-2 values. The results identified different KPs for each voice disorder; thus, disease-specific analysis is a reasonable approach.