CHANGES OF RELAXATION TIMES T-1 AND T-2 IN RAT TISSUES AFTER BIOPSY AND FIXATION
CHANGES OF RELAXATION TIMES T-1 AND T-2 IN RAT TISSUES AFTER BIOPSY AND FIXATION
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DOI：
10.1016/0730-725x(85)90353-4
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发表时间：
1985-01-01
影响因子：
2.5
通讯作者：
BERENDSEN H J C
中科院分区：
文献类型：
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作者：
KAMMAN R L;GO K G;BERENDSEN H J C
核磁共振波谱测量松弛时间的肌肉，肠，脂肪组织和大脑皮质和白质在不同的时间间隔后，大鼠的组织。结果表明，大多数组织可以在4℃下保存。C长达24小时，对核磁共振弛豫参数没有明显影响。除肌肉的T2和肠道的T1、T2在活检后1小时内有变化趋势外，其余均无明显变化。松弛参数在组织固定后有较大变化。因此，在对固定的组织进行核磁共振测量时，必须考虑固定的影响。
NMR spectroscopical measurements of relaxation times were conducted on muscle, intestine, fatty tissue and cerebral cortex and white matter of the rat at various time intervals following removal of the tissue. It appeared that most tissues can be stored at 4.degree. C up to 24 hours without noticeable effects on NMR relaxation parameters. Exceptions are the T2 of muscle and the T1 and T2 of intestine, which tended to change in the first hour after biopsy. Relaxation parameters change considerably after fixation of the tissues. Therefore the effects of fixation have to be taken into account when carrying out NMR measurements on fixed tissues.