Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?
Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?
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DOI：
10.1155/2020/4389089
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发表时间：
2020-05-30
影响因子：
--
通讯作者：
Pascarella, Stefano
中科院分区：
文献类型：
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作者：
Bianchi, Martina;Benvenuto, Domenico;Pascarella, Stefano
2019冠状病毒病（COVID-19）是由严重急性呼吸道冠状病毒2（SARS-CoV-2）引起的新型病毒感染。基因组分析显示，SARS-CoV-2与穿山甲和蝙蝠冠状病毒有关。在这份报告中，从不同的人分离的SARS冠状病毒2包膜和膜蛋白与同源蛋白从密切相关的病毒之间的结构比较进行了描述。本文报道的分析表明，包膜蛋白和膜蛋白与穿山甲和蝙蝠冠状病毒分离株的对应物具有高度的结构相似性。然而，这些比较也突出了Sars-CoV-2蛋白的特异性结构差异，这可能与跨物种传播和/或病毒的特性相关。结构建模已被应用到映射到预测的三维结构的包膜和膜蛋白的变异位点。
The Coronavirus Disease 2019 (COVID-19) is a new viral infection caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2). Genomic analyses have revealed that SARS-CoV-2 is related to Pangolin and Bat coronaviruses. In this report, a structural comparison between the Sars-CoV-2 Envelope and Membrane proteins from different human isolates with homologous proteins from closely related viruses is described. The analyses here reported show the high structural similarity of Envelope and Membrane proteins to the counterparts from Pangolin and Bat coronavirus isolates. However, the comparisons have also highlighted structural differences specific of Sars-CoV-2 proteins which may be correlated to the cross-species transmission and/or to the properties of the virus. Structural modelling has been applied to map the variant sites onto the predicted three-dimensional structure of the Envelope and Membrane proteins.