Part of the RBM gene cluster is located distally to the DAZ gene cluster in human Yq11.23
Part of the RBM gene cluster is located distally to the DAZ gene cluster in human Yq11.23
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DOI：
10.1023/a:1008850819150
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发表时间：
1997-12-01
影响因子：
2.6
通讯作者：
Schempp, W
中科院分区：
文献类型：
--
作者：
Pasantes, JJ;Rottger, S;Schempp, W
选择正常人Y和倒置Y染色体进行RBM和DAZ探针的物理荧光原位杂交（FISH）作图，用于人Y染色体间隔6中RBM和DAZ基因簇的相对定位。Yq11.23中的倒位断点被证明是DAZ基因簇的远端，因为整个DAZ信号出现在inv（Y）染色体的短臂中。相反，Yq11.23中的这个倒位断点将RBM信号簇分开，在长臂上留下较弱的信号，同时将主要的RBM信号带到inv（Y）染色体的短臂。因此，可以得出结论，与先前的权利要求相反，RBM基因簇的一部分位于人Y染色体的缺失间隔6中DAZ基因簇的远端。
Normal human Y and inverted Y chromosomes were chosen for physical fluorescence in situ hybridization (FISH) mapping of RBM and DAZ probes for the relative positioning of the RBM and DAZ gene clusters in interval 6 of the human Y chromosome. The inversion breakpoint in Yq11.23 turned out to be distal to the DAZ gene cluster, as the entire DAZ signal appears in the short arm of the inv(Y) chromosome. On the contrary, this inversion breakpoint in Yq11.23 divides the RBM signal cluster, leaving a weaker signal on the long arm while bringing the main RBM signal to the short arm of the inv(Y) chromosome. Thus, it can be concluded that, in contrast to previous claims, part of the RBM gene cluster is located distally to the DAZ gene cluster in deletion interval 6 of the human Y chromosome.