Disruption of the MacMARCKS gene prevents cranial neural tube closure and results in anencephaly
Disruption of the MacMARCKS gene prevents cranial neural tube closure and results in anencephaly
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DOI：
10.1073/pnas.93.13.6275
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发表时间：
1996-06-25
影响因子：
11.1
通讯作者：
Aderem, A
中科院分区：
文献类型：
--
作者：
Chen, JM;Chang, S;Aderem, A
MacMARCKS是蛋白激酶C（PKC）底物MARCKS家族的成员。生化证据表明，这些蛋白质整合钙和PKC依赖的信号，以调节肌动蛋白结构的膜，我们在这里报告的MacMARCKS基因的缺失，防止颅神经管关闭在发育中的大脑，导致无脑畸形。这表明MacMARCKS和PKC信号转导通路在脑形成的早期阶段前神经板的折叠中起核心作用，并支持肌动蛋白为基础的运动指导颅神经管关闭的假设。
MacMARCKS is a member of the MARCKS family of protein kinase C (PKC) substrates. Biochemical evidence demonstrates that these proteins integrate calcium and PKC-dependent signals to regulate actin structure at the membrane, We report here that deletion of the MacMARCKS gene prevents cranial neural tube closure in the developing brain, resulting in anencephaly. This suggests a central role for MacMARCKS and the PKC signal transduction pathway in the folding of the anterior neural plate during the early phases of brain formation, and supports the hypothesis that actin-based motility directs cranial neural tube closure.