Everyday Executive Function and Self-Awareness in Agenesis of the Corpus Callosum.
Everyday Executive Function and Self-Awareness in Agenesis of the Corpus Callosum.
复制标题
DOI：
10.1017/s1355617721000096
复制
发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Paul LK
中科院分区：
文献类型：
--
作者：
Mangum RW;Miller JS;Brown WS;Nolty AAT;Paul LK
胼胝体（AgCC）的发育与一系列认知缺陷相关，包括神经心理学评估中明显的高阶执行功能的轻度至中度问题。以前的研究也表明AgCC患者缺乏自我意识。我们调查了日常执行功能和自我意识的36个人与AgCC通过分析自我评级的行为评定量表的执行功能成人版（BRIEF-A），以及在同一仪器上的评级从近亲。自我和线人评级之间的差异进行了比较，规范的样本和探索性分析研究可能的调节作用的参与者和线人的特点。显着的缺陷被发现在行为调节和元认知指数的自我和线人的结果，与元认知分数的边缘到临床范围内的频率升高。知情者还认可边缘到临床显著行为调节评分的频率升高。AgCC参与者的比例，其自我评级表明较少的元认知障碍比线人评级是大于规范样本。行为调节障碍的自我评定随着年龄的增长而降低，元认知的被试评定男性高于女性。这些研究结果提供了证据表明，AgCC患者在日常行为中遇到了轻度至中度的执行功能问题，这些问题被其他人观察到。结果还表明，缺乏自我理解或洞察这些问题的严重性，在个人与AgCC，特别是关于他们的元认知功能。
Agenesis of the corpus callosum (AgCC) is associated with a range of cognitive deficits, including mild to moderate problems in higher order executive functions evident in neuropsychological assessments. Previous research has also suggested a lack of self-awareness in persons with AgCC. We investigated daily executive functioning and self-awareness in 36 individuals with AgCC by analyzing self-ratings on the Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A), as well as ratings on the same instrument from close relatives. Discrepancies between self- and informant-ratings were compared to the normative sample and exploratory analyses examined possible moderating effects of participant and informant characteristics. Significant deficiencies were found in the Behavioral Regulation and Metacognitive indices for both the self and informant results, with elevated frequency of metacognition scores in the borderline to clinical range. Informants also endorsed elevated frequency of borderline to clinically significant behavioral regulation scores. The proportion of AgCC participants whose self-ratings indicated less metacognitive impairment than informant-ratings was greater than in the normative sample. Self-ratings of behavioral regulation impairment decreased with age and informant-ratings of metacognition were higher in males than females. These findings provide evidence that individuals with AgCC experience mild to moderate executive functioning problems in everyday behavior which are observed by others. Results also suggest a lack of self-understanding or insight into the severity of these problems in the individuals with AgCC, particularly with respect to their metacognitive functioning.