Reduction of respiratory motion artifacts in PET imaging of lung cancer by respiratory correlated dynamic PET: methodology and comparison with respiratory gated PET.
Reduction of respiratory motion artifacts in PET imaging of lung cancer by respiratory correlated dynamic PET: methodology and comparison with respiratory gated PET.
复制标题
通过呼吸相关动态 PET 减少肺癌 PET 成像中的呼吸运动伪影：方法以及与呼吸门控 PET 的比较。
作者：
S. Nehmeh;Y. Erdi;K. Rosenzweig;H. Schoder;S. Larson;O. Squire;J. Humm
无标签
这项研究提出了一种减少肺癌 PET 图像中呼吸运动伪影的新方法。该方法称为呼吸相关动态 PET (RCDPET)。 RCDPET 无需呼吸跟踪设备即可采集 4 维 PET 数据。在本文中，我们将此方法与呼吸门控 PET (RGPET) 进行比较。两种方法都能够校正运动伪影并更准确地定量肺部病变内放射性示踪剂的吸收。这两种方法均在模型研究和 1 名患者中进行了评估。
方法
使用 RCDPET，可以在连续 1 秒的时间帧内采集数据。将连接到硬质泡沫块的点源设置在患者腹部，并通过低密度杆将其延伸到病变水平处的摄像机视野中。该源的位置用于通过连续的动态帧跟踪呼吸运动。然后在扫描后识别与呼吸周期内用户选择的病变位置对应的图像帧，与点源位置相关。对所选图像帧的正弦图进行求和，然后使用具有分段衰减校正的迭代重建来重建。
结果
RGPET 和 RCDPET 的模型研究结果在活性定量和图像噪声水平方面的一致性在 10% 以内。在临床应用中，RCDPET 和 RGPET 测量之间的 SUV(max) 定量和病变大小分别显示 6% 和 2% 的差异。
结论
RCDPET 可被视为 RGPET 的可比或替代方法，可减少呼吸引起的涂抹效应并改善胸部 PET 的定量。 RCDPET 相对于 RGPET 的优势之一是能够回顾性重建呼吸周期中任何相位或幅度的 PET 数据。
UNLABELLED
This study proposes a new method to reduce respiratory motion artifacts in PET images of lung cancer. The method is referred to as respiratory-correlated dynamic PET (RCDPET). RCDPET enables the acquisition of 4-dimensional PET data without the need for a respiratory tracking device. In this article, we compare this method with respiratory-gated PET (RGPET). Both methods provide the ability to correct for motion artifacts and more accurately quantitate radiotracer uptake within lung lesions. Both methods were evaluated in phantom studies and 1 patient.
METHODS
With RCDPET, data are acquired in consecutive 1-s time frames. A point source attached to a rigid foam block is set on the patient's abdomen and is extended into the camera field of view at the level of the lesion by means of a low-density rod. The position of this source is used to track respiratory motion through the consecutive dynamic frames. Image frames corresponding to a user-selected lesion position within the breathing cycle, in correlation with the point source position, are then identified after scanning. The sinograms of the selected image frames are summed and then reconstructed using iterative reconstruction with segmented attenuation correction.
RESULTS
The results from phantom studies with both RGPET and RCDPET were within 10% agreement, for both activity quantitation and image noise levels. In a clinical application, the quantitation of the SUV(max) and the lesion's size showed a 6% and 2% difference, respectively, between RCDPET and RGPET measurements.
CONCLUSION
RCDPET can be considered as a comparable, or alternative, method to RGPET in reducing the smearing effects due to respiration and improving quantitation of PET in the thorax. One advantage of RCDPET over RGPET is the ability to retrospectively reconstruct the PET data at any phase or amplitude in the breathing cycle.
DOI：
10.1016/s0360-3016(00)00747-1
发表时间：
2000-11-01
影响因子：
7
作者：
Mah, D;Hanley, J;Mageras, G
通讯作者：
Mageras, G