Increased serum levels of aldehydes are associated with cardiovascular disease and cardiovascular risk factors in adults
Increased serum levels of aldehydes are associated with cardiovascular disease and cardiovascular risk factors in adults
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血清醛类水平升高与成人心血管疾病和心血管危险因素相关
DOI：
10.1016/j.jhazmat.2020.123134
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发表时间：
2020-12-05
影响因子：
13.6
通讯作者：
Gu, Aihua
中科院分区：
文献类型：
--
作者：
Xu, Cheng;Liang, Jingjia;Gu, Aihua
以前的研究已经确定了几个心血管疾病(CVD)的遗传和环境风险因素，但对血清醛和CVD风险之间的关系知之甚少。在这里，我们研究了1947名参加2013-2014年国家健康和营养检查调查(NHANES)的美国成年人的血清醛水平与心血管疾病及其亚型风险之间的关系。采用贝叶斯核机回归(BKMR)分析血清醛类物质对心血管疾病总体风险的综合影响。我们发现异戊醛浓度与心血管疾病的发病几率呈正相关(调整后的优势比(AOR)：2.17；95%可信区间(95%CI)：1.36，3.46)。BKMR的结果还表明，混合醛与心血管疾病风险呈正相关。异戊醛的后方夹杂概率最高(PIP=0.90)。在完全调整的模型中，异戊醛浓度每增加一个单位，甘油三酯增加25.0 mg/dL，白细胞计数增加0.9x10(9)/L。目前的证据表明，异戊醛可能通过增加甘油三酯和白细胞计数而增加患心血管疾病的风险。
Previous studies have identified several genetic and environmental risk factors for cardiovascular disease (CVD), but little is known about the associations between serum aldehydes and CVD risk. Herein, we examined associations between serum levels of aldehydes and the risk of CVD and CVD subtypes among 1947 U.S. adults participating in the National Health and Nutrition Examination Survey (NHANES) 2013 - 2014. Bayesian kernel machine regression (BKMR) was used to analyze the combined effect of serum aldehydes on the overall risk of CVD. We found that isopentanaldehyde concentrations were positively associated with the odds of CVD (adjusted odds ratio (aOR): 2.17; 95 % confidence interval (95 % CI): 1.36, 3.46). The result of BKMR also indicated a positive association of mixed aldehydes with CVD risk. Isopentanaldehyde had the highest posterior inclusion probabilities (PIP = 0.90). Each one-unit (ng/mL) increase in the isopentanaldehyde concentration was associated with a 25.0 mg/dL increase in triglycerides and a 0.9 x 10(9)/L increase in white blood cell (WBC) count in the fully adjusted model. Current evidence suggests that isopentanaldehyde may increase the risk of CVD by elevating triglycerides and WBC count.