Increased trend in extracorporeal membrane oxygenation use by adults in the United States since 2007.
Increased trend in extracorporeal membrane oxygenation use by adults in the United States since 2007.
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DOI：
10.1186/s13104-015-1678-7
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发表时间：
2015-11-18
影响因子：
1.8
通讯作者：
Polgreen, Philip M
中科院分区：
文献类型：
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作者：
Gerke, Alicia K;Tang, Fan;Polgreen, Philip M
背景技术背景：体外膜肺氧合（ECMO）作为一种生命支持方式已被越来越多地研究，但尚不清楚其使用是否随时间而变化。最近的出版物显示，随着时间的推移，ECMO的使用没有明显的趋势;然而，本报告不包括最新的数据。我们进行了趋势分析，以确定是否以及何时使用ECMO改变在过去decenture.RESULTS：我们确定了住院（2000-2011年）在全国范围内的住院患者样本期间，ECMO被记录。我们使用分段线性回归模型来确定趋势，并确定ECMO使用率增加时的时间变化点。ECMO的使用逐渐增加，直到2007年，当时的比率急剧增加（p = 0.0003）。2007年后的死亡率没有差异（p = 0.3374），但住院时间更长（p = 0.0001），女性比例更小（p = 0.005）。结论：自2007年以来，ECMO的使用显著增加。随着ECMO的使用越来越普遍，有必要进一步研究适应症，成本效益和结果，以指导最佳使用。
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) has been increasingly studied as a life support modality, but it is unclear if its use has changed over time. Recent publication shows no significant trend in use of ECMO over time; however, this report does not include more recent data. We performed trend analysis to determine if and when the use of ECMO changed in the past decade.RESULTS: We identified hospitalizations (2000-2011) in the Nationwide Inpatient Sample during which ECMO was recorded. We used a segmented linear regression model to determine trend and to identify a temporal change point when rate of ECMO use increased. ECMO use gradually grew until 2007, at which time there was a dramatic increase in the rate (p = 0.0003). There was no difference in mortality after 2007 (p = 0.3374), but there was longer length of stay (p = 0.0001) and smaller percentage of women (p = 0.005).CONCLUSIONS: There has been a marked increase in ECMO use since 2007. As ECMO use becomes more common, further study regarding indications, cost-effectiveness, and outcomes is warranted to guide optimal use.