Immuno-reactive and bioactive corticotropin-releasing factor in rat thymus.
Immuno-reactive and bioactive corticotropin-releasing factor in rat thymus.
复制标题
大鼠胸腺中的免疫反应性和生物活性促肾上腺皮质激素释放因子。
DOI：
10.1159/000126104
复制
发表时间：
1992
影响因子：
4.1
通讯作者：
Redei,E
中科院分区：
文献类型：
--
作者：
Redei,E
用放射免疫法测定大鼠胸腺提取液中免疫反应性促肾上腺皮质激素释放因子(CRF)的含量。胸腺提取液、下丘脑提取液和合成CRF标准曲线的系列稀释度。从大鼠胸腺中提取的CRF在Sephadex G-25柱上洗脱于合成的大鼠CRF的位置。胸腺来源的CRF具有生物学活性，刺激分散的大鼠垂体前叶细胞分泌促肾上腺皮质激素。这些发现表明在大鼠胸腺中存在真实的CRF，进一步支持了神经内分泌-免疫反应对环境刺激的综合调节的概念。
Immunorective corticotropin-releasing factor (CRF) was identified and measured by radioimmunossay in rat thymic extract. Serial dilutions of thymic extract paralleled hypothalamic extract and synthetic CRF standard curves. CRF extracted from rat thymus eluted in the position of synthetic rat CRF on Sephadex G-25 column. Thymus-derived CRF was biologically active as demonstrated by stimulating adrenocorticotropic hormone secretion in dispersed rat anterior pituitary cells. These findings indicate the presence of authentic CRF in rat thymus, further supporting the concept of an integrated regulation of the neuroendocrine-immune responses to environmental stimuli.