Histopathological correlation of oral squamous cell carcinoma among younger and older patients.
Histopathological correlation of oral squamous cell carcinoma among younger and older patients.
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DOI：
10.4103/0973-029x.140734
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Ahmed Mujib B
中科院分区：
文献类型：
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作者：
Ur Rahaman SM;Ahmed Mujib B
口腔鳞状细胞癌（Oral Squamous Cell Carcinoma，OSCC）好发于老年男性，当发生在年轻个体时，其侵袭性和预后受到质疑，因为文献中的数据存在偏差。传统上，各种组织病理学分级系统已被用于评估口腔鳞癌的侵袭性和预后。然而，Anneroth等人的多因素分级，被视为有效。在这项回顾性前瞻性研究中，从口腔病理科检索了75例OSCC患者的档案，其中50例患者>40岁，25例患者≤40岁。用福尔马林固定石蜡包埋的组织块制备苏木精和伊红（H和E）染色切片，根据Broder和Anneroth等人的方法对OSCC进行分级，的搜索.此外，研究对象在治疗后5年内的口腔鳞状细胞癌复发情况也进行了评估。年龄>40岁与≤40岁患者的病情比较采用卡方检验。根据Broder分类的比较没有显示出任何相关的变化。根据Anneroth等人的6个参数中的3个和总体分级，标准显示年轻年龄组的口腔鳞状细胞癌分级在统计学上更高;然而，5年复发率没有显著差异。研究结果提示，与老年患者相比，年轻患者中的侵袭性OSCC。相反，这种攻击性并不影响年轻患者的复发。进一步研究40岁以下口腔鳞癌患者的遗传学、饮食和人口统计学特征将具有更大价值。
Oral Squamous Cell Carcinoma (OSCC) is commonly noted in elder men, when occurring in younger individuals, its aggression and prognosis is questioned due to biased data in literature. Traditionally, various histopathological grading systems have been used for assessing aggression and prognosis of OSCC. However, multifactorial grading of Anneroth et al., is considered effective. In this retro-prospective study, files of 75 OSCC patients were retrieved from Oral Pathology Department; among this 50 patients were >40 years and 25 patients were ≤40 years of age. Archival formalin fixed paraffin embedded tissue blocks of these patients were used to prepare hematoxylin and eosin (H and E) stained sections for grading OSCC based on Broder's and Anneroth et al., criteria. Further, recurrence of OSCC among study subjects within 5 years of treatment was evaluated. Chi-square test was used to compare the disease in patients who were >40 years with ≤40 years. Comparison according to Broder's classification didn’t show any relevant variation. Three of the six parameters and overall grading according to Anneroth et al., criteria showed statistically higher grades of OSCC in the younger age-group; however, there was no significant difference in 5-year recurrence rate. Results of the study are suggestive of aggressive OSCC among young patients when compared to older. Conversely, this aggression didn’t affect the recurrence in younger patients. Further studies on genetics, diet and demographics of patients below 40 years of age affected by OSCC will be of greater value.