Positive association between serum level of glyceraldehyde-derived advanced glycation end products and vascular inflammation evaluated by [(18)F]fluorodeoxyglucose positron emission tomography.
Positive association between serum level of glyceraldehyde-derived advanced glycation end products and vascular inflammation evaluated by [(18)F]fluorodeoxyglucose positron emission tomography.
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DOI：
10.2337/dc12-0087
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发表时间：
2012-12
期刊：
影响因子：
16.2
通讯作者：
Imaizumi T
中科院分区：
文献类型：
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作者：
Tahara N;Yamagishi S;Takeuchi M;Honda A;Tahara A;Nitta Y;Kodama N;Mizoguchi M;Kaida H;Ishibashi M;Hayabuchi N;Matsui T;Imaizumi T
晚期糖基化终产物（AGEs）引起炎症反应，促进动脉粥样硬化的发生和发展。探讨血清AGE水平与血管炎症的关系。该研究涉及日本Kurdom大学的275名门诊患者（189名男性和86名女性;平均年龄61.2 ± 8.8岁），他们接受了完整的病史和体格检查，并测定了血液化学和人体测量变量，包括AGEs。采用酶联免疫吸附法检测血清AGE水平。血管[18F]氟脱氧葡萄糖（FDG）摄取是血管炎症的一个指标，通过FDG-正电子发射断层扫描（FDG-PET）测量为血液标准化标准化摄取值，称为靶背景比（TBR）。此外，我们还检查了另18例AGE值>14.2单位/mL（平均值± 2 SD）的受试者口服降糖药（OHA）治疗后血清AGE水平的变化是否与TBR的变化相关。平均血清AGE水平和颈动脉TBR值分别为9.15 ± 2.53和1.43 ± 0.22单位/mL。多元逐步回归分析显示TBR与AGEs（P < 0.001）、颈动脉内膜中层厚度（P < 0.01）和BMI（P < 0.02）独立相关。当使用ANCOVA比较按TBR三分位数分层的年龄和性别校正的AGE值时，观察到显著趋势（P < 0.01）。OHA治疗后AGEs变化与TBR值变化呈正相关（r = 0.50，P < 0.05）。目前的研究表明，血清AGE水平与FDG-PET评价的血管炎症独立相关，表明循环AGE值可能是反映动脉粥样硬化区域内血管炎症的生物标志物。
Advanced glycation end products (AGEs) evoke inflammatory reactions, contributing to the development and progression of atherosclerosis. We investigated the relationship between serum AGE level and vascular inflammation. The study involved 275 outpatients at Kurume University, Japan (189 males and 86 females; mean age 61.2 ± 8.8 years) who underwent complete history and physical examinations and determinations of blood chemistry and anthropometric variables, including AGEs. Serum AGE level was examined by enzyme-linked immunosorbent assay. Vascular [18F]fluorodeoxyglucose (FDG) uptake, an index of vascular inflammation, was measured as blood-normalized standardized uptake value, known as the target-to-background ratio (TBR), by FDG–positron emission tomography (FDG-PET). Furthermore, we examined whether the changes in serum AGE level after treatment with oral hypoglycemia agents (OHAs) were correlated with those of TBR in another 18 subjects whose AGE value was >14.2 units/mL (mean ± 2 SD). Mean serum AGE level and carotid TBR values were 9.15 ± 2.53 and 1.43 ± 0.22 units/mL, respectively. Multiple stepwise regression analysis revealed that TBR was independently correlated with AGEs (P < 0.001), carotid intima-media thickness (P < 0.01), and BMI (P < 0.02). When age- and sex-adjusted AGE values stratified by TBR tertiles were compared using ANCOVA, a significant trend was observed (P < 0.01). In addition, the changes in AGEs after OHA treatment were positively (r = 0.50, P < 0.05) correlated with those in TBR value. The current study reveals that serum AGE level is independently associated with vascular inflammation evaluated by FDG-PET, suggesting that circulating AGE value may be a biomarker that could reflect vascular inflammation within an area of atherosclerosis.