Prenatal exposure to persistent organic pollutants and organophosphate pesticides, and markers of glucose metabolism at birth
Prenatal exposure to persistent organic pollutants and organophosphate pesticides, and markers of glucose metabolism at birth
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DOI：
10.1016/j.envres.2016.01.005
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发表时间：
2016-04-01
影响因子：
8.3
通讯作者：
Cordier, Sylvaine
中科院分区：
文献类型：
--
作者：
Debost-Legrand, Anne;Warembourg, Charline;Cordier, Sylvaine
背景资料：实验证据表明，发育过程中接触持久性有机污染物（POP）和一些非持久性农药可能会破坏葡萄糖代谢和胰岛素分泌的代谢调节，从而导致当前肥胖和代谢紊乱的流行。子宫内营养不良的准实验性情况提供了一些信息。然而，关于产前环境在这些疾病中的作用的人类证据是矛盾的，并且对产前暴露的长期结果（如2型糖尿病）知之甚少。目的：我们的目的是评估产前暴露于持久性有机污染物和有机磷农药对来自布列塔尼（法国）Pelagie母子队列的新生儿样本中胎儿葡萄糖代谢标志物的影响。方法：二烷基磷酸盐（DAP）的有机磷农药代谢产物进行了测量，在怀孕开始时收集的母亲尿液。结果：268例新生儿脐血中脂联素和胰岛素水平均随DDE浓度的升高而降低，但仅在女孩中存在，而在男孩中不存在。脂联素水平与其他POP或DAP代谢产物的浓度无关。随着PCB 153浓度的增加，观察到胰岛素水平降低。胰岛素水平随尿DAP水平升高而升高。额外调整BMI Z-分数在出生时修改了一些这些relations.Conclusions：我们的观察带来了支持的潜在作用，有机磷农药和持久性有机污染物在出生时观察到的葡萄糖代谢的改变。(C)2016 Elsevier Inc. All rights reserved.
Background: Experimental evidence suggests that developmental exposure to persistent organic pollutants (POP) and to some non persistent pesticides may disrupt metabolic regulation of glucose metabolism and insulin secretion, and thereby contribute to the current epidemic of obesity and metabolic disorders. Quasi-experimental situations of undernutrition in utero have provided some information. However, the evidence in humans concerning the role of the prenatal environment in these disorders is contradictory, and little is known about long-term outcomes, such as type 2 diabetes, of prenatal exposure.Objectives: Our aim was to evaluate the effects of prenatal exposure to POP and organophosphate pesticides on fetal markers of glucose metabolism in a sample of newborns from the Pelagie mother child cohort in Brittany (France).Methods: Dialkylphosphate (DAP) metabolites of organophosphate pesticides were measured in maternal urine collected at the beginning of pregnancy. Cord blood was assayed for polychlorinated biphenyl congener 153 (PCB153), p,p'-dichlorodiphenyl dichloroethene (DDE) and other POP. Insulin and adiponectin were determined in cord blood serum (n=268).Results: A decrease in adiponectin and insulin levels was observed with increasing levels of DDE, but only in girls and not boys. Adiponectin levels were not related to the concentrations of other POP or DAP metabolites. Decreasing insulin levels were observed with increasing PCB153 concentrations. Insulin levels increased with DAP urinary levels. Additional adjustment for BMI z-score at birth modified some of these relations.Conclusions: Our observations bring support for a potential role of organophosphate pesticides and POP in alterations to glucose metabolism observable at birth. (C) 2016 Elsevier Inc. All rights reserved.