Reconfigured functional network dynamics in adult moyamoya disease: a resting-state fMRI study
Reconfigured functional network dynamics in adult moyamoya disease: a resting-state fMRI study
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成人烟雾病的功能网络动态重构：静息态功能磁共振成像研究
DOI：
10.1007/s11682-018-0009-8
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发表时间：
2020-06-01
影响因子：
3.2
通讯作者：
Mao, Ying
中科院分区：
文献类型：
--
作者：
Lei, Yu;Song, Benshen;Mao, Ying
成人烟雾病（MMD）的血管性认知障碍（VCI）的治疗尚不清楚，因为它的神经同步性尚不清楚。本研究引入连接数熵（CNE）的动态测量来表征网络相互作用的空间和时间维度。招募了51名烟雾病患者（27名VCI患者，24名认知完整患者），以及26名正常对照（nc）。首先检测静态网络特性，以确认其在VCI MMD中的异常。然后，利用CNE的动态测量来检测VCI在全球、区域和网络层面上MMD灵活性的恶化。最后，在三个群体中跟踪了灵活和专业化区域的动态重构。图论分析表明，烟雾病表现为“小世界”网络拓扑，但随着疾病的发展，在整合、隔离和小世界的所有拓扑指标上都呈现出偏离NC的模式。随后的动态分析显示，三组在全局（p< 0.001）和网络水平（默认模式网络，p= 0.004；执行控制网络，p= 0.001）上的CNE均存在显著差异。具体来说，与信息处理关键方面相关的大脑区域在三组中表现出显著的CNE变化。此外，灵活区和专门化区的CNE值随认知损伤而改变。本研究不仅首次揭示了成人烟雾病网络变化背后的静态和动态组织原理，而且为进一步了解其病理生理和治疗方向提供了新的方法学观点。
Treatment of vascular cognitive impairment (VCI) in adult moyamoya disease (MMD) is still unclear because of its unveiled neural synchronization. This study introduced a dynamic measurement of connectivity number entropy (CNE) to characterize both spatial and temporal dimensions of network interactions. Fifty-one patients with MMD were recruited (27 with VCI and 24 with intact cognition), as well as 26 normal controls (NCs). Static network properties were first examined to confirm its aberrance in MMD with VCI. Then, the dynamic measurement of CNE was used to detect the deteriorated flexibility of MMD with VCI at global, regional, and network levels. Finally, dynamic reconfiguration of flexible and specialized regions was traced across the three groups. Graph theory analysis indicated that MMD exhibited “small-world” network topology but presented with a deviating pattern from NC as the disease progressed in all topologic metrics of integration, segregation, and small-worldness. Subsequent dynamic analysis showed significant CNE differences among the three groups at both global (p< 0.001) and network levels (default mode network,p= 0.004; executive control network,p= 0.001). Specifically, brain regions related to key aspects of information processing exhibited significant CNE changes across the three groups. Furthermore, CNE values of both flexible and specialized regions changed with impaired cognition. This study not only sheds light on both the static and dynamic organizational principles behind network changes in adult MMD for the first time, but also provides a new methodologic viewpoint to acquire more knowledge of its pathophysiology and treatment direction.