The roles of nectins in cell adhesions: cooperation with other cell adhesion molecules and growth factor receptors
The roles of nectins in cell adhesions: cooperation with other cell adhesion molecules and growth factor receptors
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DOI：
10.1016/j.ceb.2007.09.007
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发表时间：
2007-10-01
影响因子：
7.5
通讯作者：
Takai, Yoshimi
中科院分区：
文献类型：
--
作者：
Sakisaka, Toshiaki;Ikeda, Wataru;Takai, Yoshimi
Nectin是一种钙离子非依赖性的Ig样细胞粘附分子（CAM），与Nectin相互作用形成细胞间粘附。这种细胞-细胞粘附参与许多类型的细胞-细胞连接的形成，如粘附连接、紧密连接和突触连接，与其他CAM如钙粘蛋白和紧密连接蛋白协同作用。连接素与整合素α（v）β（3）协同信号传导，并调节细胞-细胞连接的形成。此外，nectin与PDGF受体顺式相互作用并调节其抗凋亡信号传导。此外，nectin与nectin样分子-5（Necl-5）反式相互作用并调节细胞运动和增殖。我们描述了与其他CAM和生长因子受体的nectin的合作作用。
Nectins are Ca2+ -independent Ig-like cell adhesion molecules (CAMs) which homophilically and heterophilically interact in trans with nectins and form cell-cell adhesion. This cell-cell adhesion is involved in the formation of many types of cell-cell junctions such as adherens junctions, tight junctions, and synaptic junctions, cooperatively with other CAMs such as cadherins and claudins. Nectins transduce signals cooperatively with integrin alpha(v)beta(3), and regulate formation of cell-cell junctions. In addition, nectin interacts in cis with PDGF receptor and regulates its signaling for anti-apoptosis. Furthermore, nectin interacts in trans with nectin-like molecule-5 (Necl-5) and regulate cell movement and proliferation. We describe cooperative roles of nectins with other CAMs and growth factor receptors.