Intensity-modulated radiotherapy improves outcomes in postoperative patients with squamous cell carcinoma of the oral cavity
Intensity-modulated radiotherapy improves outcomes in postoperative patients with squamous cell carcinoma of the oral cavity
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DOI：
10.1016/j.oraloncology.2012.02.010
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发表时间：
2012-08-01
期刊：
影响因子：
4.8
通讯作者：
Wu, Yuan-Hua
中科院分区：
文献类型：
--
作者：
Chen, Pang-Yu;Chen, Helen H. W.;Wu, Yuan-Hua
目的：比较口腔鳞癌术后常规放疗(RT)和调强放疗(IMRT)患者的预后和生存率。材料和方法：对2005年1月至2008年9月在国立成功大学附属医院放射肿瘤科连续接受放射治疗的131例口腔鳞癌患者的临床资料进行分析。根据术后常规放疗或调强放疗分为两组。结果：常规放疗组和调强放疗组患者3年生存率的Kaplan-Meier估计值分别为51.2%和69.4%(p=0.079)。调强放疗组的3年局部区域控制率(53.5%vs.76.3%；p=0.020)和无瘤生存率(47.8%vs.70.0%；p=0.027)显著提高。这项回顾研究还发现，囊外扩散、切缘正/闭合(
Objectives: We compared the outcomes and survival rates of patients with oral cavity squamous cell carcinoma receiving postoperative conventional radiotherapy (RT) or intensity-modulated radiotherapy (IMRT).Materials and methods: From January 2005 to September 2008, medical records of 131 consecutive patients with oral cancer receiving postoperative radiotherapy in the Department of Radiation Oncology of National Cheng Kung University Hospital were reviewed. Patients were divided into two groups according to the administration of postoperative conventional RT or IMRT. The loco-regional control, survival, and other prognostic factors were compared.Results: The 3-year Kaplan-Meier estimates of overall survival for patients receiving conventional RT and IMRT groups were 51.2% vs. 69.4% (p = 0.079), respectively. The 3-year local-regional control (53.5% vs. 76.3%; p = 0.020) and disease-free survival rates (47.8% vs. 70.0%; p = 0.027) were significantly increased in the IMRT group. This retrospective study also identified that extracapsular spreading, margin positive/close (