Integrative role of the lamina terminalis in the regulation of cardiovascular and body fluid homeostasis
Integrative role of the lamina terminalis in the regulation of cardiovascular and body fluid homeostasis
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DOI：
10.1111/j.1440-1681.1996.tb02594.x
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发表时间：
1996-02-01
影响因子：
2.9
通讯作者：
Thunhorst, RL
中科院分区：
文献类型：
--
作者：
Johnson, AK;Cunningham, JT;Thunhorst, RL
1.心血管和体液动态平衡依赖于反射和行为反应的激活和协调。为了做到这一点，大脑接受并处理神经和化学输入。一旦进入大脑，来自指示心血管系统和体液平衡状态的来源的信息就会在一个广泛分布的神经网络中传播并整合。最近使用神经解剖学和功能技术的研究已经确定了这个神经网络中的几个关键区域。一个主要的处理节点由位于椎板末端的结构组成。与终板相关的结构包括正中视前核(MePO)和两个感觉环室器官(SCVO)、穹隆下器(SFO)和终板血管器官(OVLT)。目前的证据表明，血液传播的信号，如血管紧张素II(AngII)，到达SCVO(例如SFO)，在那里它们被传递。然后，这些信息通过神经通路被传递到大脑核团(例如，MePO)，在那里它与其他输入整合在一起，例如来自全身动脉血压和容量感受器的输入。由于其接受和整合功能，终板结构对于激素释放(如加压素)、交感神经激活和行为(口渴和食盐)的正常控制是必不可少的，这些共同有助于维持心血管和体液的动态平衡。
1. Cardiovascular and body fluid homeostasis depends upon the activation and co-ordination of reflexes and behavioural responses. In order to accomplish this, the brain receives and processes both neural and chemical input. Once in the brain, information from sources signalling the status of the cardiovascular system and body fluid balance travels, and is integrated, throughout a widely distributed neural network. Recent studies using neuroanatomical and functional techniques have identified several key areas within this neural network. One major processing node is comprised of structures located along the lamina terminalis.2. Structures associated with the lamina terminalis include the median preoptic nucleus (MePO) and two sensory circumventricular organs (SCVO), the subfornical organ (SFO) and the organum vasculosum of the lamina terminalis (OVLT). Current evidence indicates that blood-borne signals, such as angiotensin II(AngII), reach SCVO (e.g. SFO) where they are transduced. This information is then carried via neural pathways to brain nuclei (e.g. MePO) where it is integrated with other inputs, such as those derived from systemic arterial blood pressure and volume receptors.3. Because of their receptive and integrative functions, lamina terminalis structures are essential for the normal control of hormone release (e.g. vasopressin), sympathetic activation and behaviours (thirst and salt appetite), which collectively contribute to maintenance of cardiovascular and body fluid homeostasis.