Expression of vascular endothelial growth factors (VEGF-A/VEGF-1 and VEGF-C/VEGF-2) in postmenopausal uterine endometrial carcinoma
Expression of vascular endothelial growth factors (VEGF-A/VEGF-1 and VEGF-C/VEGF-2) in postmenopausal uterine endometrial carcinoma
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DOI：
10.1006/gyno.2000.6056
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发表时间：
2001-02-01
影响因子：
4.7
通讯作者：
Yoshihara, T
中科院分区：
文献类型：
--
作者：
Hirai, M;Nakagawara, A;Yoshihara, T
目标。我们检测了228例绝经后子宫内膜癌患者血管内皮生长因子VEGF-A/VEGF-1和VEGF-C/VEGF-2的表达，探讨其与组织病理特征和临床预后的关系。采用免疫组化方法对228例经手术治疗的绝经后子宫内膜癌患者进行VEGF-A/ VEGF-1和VEGF-C/VEGF-2的表达，并对其血管浸润、浸润深度（肌层浸润vs血清参数浸润）、淋巴管浸润、淋巴结转移、无病5年生存率（DF5YR）和无病10年生存率（DF10YR）进行统计学分析。单因素分析结果显示，VEGF-A/VEGF-1和VEGF-C/VEGF-2表达与血管浸润（P < 0.0001, P = 0.0006）、浸润深度（P = 0.0004, P = 0.043）、淋巴管浸润（P = 0.021, P < 0.0001）、淋巴结转移（P = 0.0017, P = 0.0008）、DF5YR （P = 0.0081, P = 0.0002）、DF10YR （P = 0.0077, P = 0.0001）相关。多因素分析显示，淋巴结转移（P = 0.0017, P = 0.0008）、参数化浆膜侵袭（P < 0.0001, P < 0.0001）、VEGF-C/ vegf -2阳性（P = 0.03, P = 0.01）是影响DF5YR和df10yr的重要因素。我们得出结论，VEGF-A/VEGF-1和VEGF-C/VEGF-2的表达可预测子宫内膜癌的这些组织病理特征和临床结果。(C) 2001学术出版社。
Objective. We investigated the expression of two angiogenic vascular endothelial growth factors, VEGF-A/VEGF-1 and VEGF-C/VEGF-2, in 228 cases of uterine endometrial carcinomas from postmenopausal patients to evaluate the correlation with histopathologic features and clinical outcome.Methods. Immunohistochemistry was used to assess VEGF-A/ VEGF-1 and VEGF-C/VEGF-2 expression in 228 primary surgically treated cases of postmenopausal endometrial carcinomas and the results were statistically analyzed in relation to vascular invasion, depth of invasion (myometrial vs serosal-parametrial invasion), lymphatic vessel invasion, lymph node metastasis, disease-free 5-year survival rate (DF5YR), and disease-free 10 year-survival rate (DF10YR).Results. The results of univariate analysis showed that VEGF-A/VEGF-1 and VEGF-C/VEGF-2 expression correlated with vascular invasion (P < 0.0001, P = 0.0006), depth of invasion (P = 0.0004, P = 0.043), lymphatic vessel invasion (P = 0.021, P < 0.0001), lymph node metastasis (P = 0.0017, P = 0.0008), DF5YR (P = 0.0081, P = 0.0002), and DF10YR (P = 0.0077, P = 0.0001). Multivariate analysis showed that lymph node metastasis (P = 0.0017, P = 0.0008), parametrial-serosal invasion (P < 0.0001, P < 0.0001), and VEGF-C/VEGF-2-positive status (P = 0.03, P = 0.01) were significant factors in DF5YR and DF10YR.Conclusions. We conclude that VEGF-A/VEGF-1 and VEGF-C/VEGF-2 expression was predictive of these histopathologic features of endometrial carcinoma and clinical outcome. (C) 2001 Academic Press.