EFFECTS OF L-METHIONINE (WITHOUT MAOI) IN SCHIZOPHRENIA
EFFECTS OF L-METHIONINE (WITHOUT MAOI) IN SCHIZOPHRENIA
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DOI：
10.1016/0022-3956(71)90009-4
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发表时间：
1971-01-01
影响因子：
4.8
通讯作者：
ZEALLEY, AK
中科院分区：
文献类型：
--
作者：
ANTUN, FT;BURNETT, GB;ZEALLEY, AK
采用双盲交叉设计，研究了左旋蛋氨酸（不含单胺氧化酶抑制剂）对5例正常男性和5例女性及6例男性精神分裂症患者的临床和生化影响。7例患者对甲硫氨酸表现出明确的反应，被评定为急性精神分裂症发作。本文比较了精神分裂症患者和正常人的3-甲氧基-4-羟基苯乙二醇（MHPG）排泄水平，并提出了进一步研究精神分裂症患者MHPG排泄水平升高的可能性。在蛋氨酸给药期间，MHPG或3-甲氧基-4-羟基扁桃酸的排泄未显著增加。1例患者在甲硫氨酸给药后显示出显著的临床改善。1例患者在甲硫氨酸治疗后显示出明显的临床改善，但在缺乏显著特征的情况下，得出结论认为这并不代表一种有用的治疗方法。每例精神分裂症患者的临床总结。(22参考文献）（PsycInfo数据库记录（c）2016阿帕，保留所有权利）
Studied the clinical and biochemical effects of levo-methionine (without monoamine oxidase inhibitors) on 5 normal males and 5 female and 6 male schizophrenic patients using a double blind cross-over design. 7 patients showed a clear-cut response to the methionine which was rated as an acute schizophrenic episode. Levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) excretion in schizophrenic patients and normals were compared, and further investigation of the possible elevation in schizophrenia is suggested. Excretion of MHPG or of 3-methoxy-4-hydroxymandelic acid was not significantly increased during methionine administration. One patient showed a marked clinical improvement following methionine administration. One patient showed a marked clinical improvement following methionine, but in the absence of distinguishing features it is concluded that this did not represent a useful method of treatment. Clinical summaries are presented for each of the schizophrenic patients.(22 ref.)(PsycINFO Database Record (c) 2016 APA, all rights reserved)