Prior vaccination increases the epitopic breadth of the cytotoxic T-lymphocyte response that evolves in rhesus monkeys following a simian-human immunodeficiency virus infection.
Prior vaccination increases the epitopic breadth of the cytotoxic T-lymphocyte response that evolves in rhesus monkeys following a simian-human immunodeficiency virus infection.
复制标题
先前的疫苗接种增加了恒河猴在感染人类免疫缺陷病毒后产生的细胞毒性 T 淋巴细胞反应的表位宽度。
DOI：
10.1128/jvi.76.12.6376-6381.2002
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发表时间：
2002
影响因子：
5.4
通讯作者：
Letvin,NormanL
中科院分区：
文献类型：
--
作者：
Santra,Sampa;Barouch,DanH;Kuroda,MarceloJ;Schmitz,JörnE;Krivulka,GeorgiaR;Beaudry,Kristin;Lord,CarolI;Lifton,MichelleA;Wyatt,LindaS;Moss,Bernard;Hirsch,VanessaM;Letvin,NormanL
Although recent evidence has confirmed the importance of cytotoxic T-lymphocyte (CTL) responses in controlling human immunodeficiency virus type 1 and simian immunodeficiency virus replication, the relevance of the epitopic breadth of those CTL responses remains unexplored. In the present study, we sought to determine whether vaccination can expand CTL populations which recognize a repertoire of viral epitopes that is greater than is typically generated in the course of a viral infection. We demonstrate that potent secondary CTL responses to subdominant epitopes are rapidly generated following a pathogenic simian-human immunodeficiency virus challenge of rhesus monkeys vaccinated with plasmid DNA or recombinant modified vaccinia virus Ankara vaccines. These data indicate that prior vaccination can increase the breadth of the CTL response that evolves after an AIDS virus infection.
