Experimental Periodontitis Induces Gene Expression of Proinflammatory Cytokines in Liver and White Adipose Tissues in Obesity
Experimental Periodontitis Induces Gene Expression of Proinflammatory Cytokines in Liver and White Adipose Tissues in Obesity
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DOI：
10.1902/jop.2009.090574
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发表时间：
2010-04-01
影响因子：
4.3
通讯作者：
Morita, Manabu
中科院分区：
文献类型：
--
作者：
Endo, Yasumasa;Tomofuji, Takaaki;Morita, Manabu
背景：近年来的研究表明牙周炎可引起全身性低度炎症。牙周炎引起的系统性低度炎症的增加可能改变肥胖对肝脏和白色脂肪组织（WAT）中炎症分子（包括C-反应蛋白（CRP）、白细胞介素（IL）-6和肿瘤坏死因子-α（TNF-α））产生的影响。本研究的目的是研究牙周炎对肥胖Zucker大鼠肝脏和WAT中促炎细胞因子表达的影响。方法：将肥胖Zucker大鼠及其同窝瘦鼠分为4组，每组6只：无牙周炎的瘦Zucker大鼠（对照组），患有牙周炎的瘦Zucker大鼠（牙周炎组）、无牙周炎的肥胖Zucker大鼠（肥胖组）和有牙周炎的肥胖Zucker大鼠（组合组）。牙周炎结扎诱导4周的牙周炎和组合groups，而其他组是左unligated.Results：在4周，CRP，IL-6，TNF-α的基因表达在肝脏和CRP和IL-6的WAT的组合组是显着高于每三个组。牙周炎组和肥胖组血清TNF-α水平明显高于对照组。血清CRP和TNF-α的组合组是显着高于在每个的3 groups.Conclusion：实验性牙周炎后全身低度炎症与基因表达增加的肝脏水平的TNF-α和CRP和脂肪组织水平的IL-6和CRP在肥胖大鼠模型。J Periodontol 2010;81：520-526.
Background: Recent studies indicated that periodontitis induces systemic low-grade inflammation. The increase in systemic low-grade inflammation induced by periodontitis may alter the effects of obesity on the production of inflammatory molecules, including C-reactive protein (CRP), interleukin (IL)-6, and tumor necrosis factor-alpha (TNF-alpha), in the liver and white adipose tissue (WAT). The purpose of the present study is to investigate the effects of periodontitis on the expression of proinflammatory cytokines in the liver and WAT in obese Zucker rats.Methods: Obese Zucker rats and their lean litter mates were divided into four groups of six rats each: lean Zucker rats without periodontitis (control group), lean Zucker rats with periodontitis (periodontitis group), obese Zucker rats without periodontitis (obesity group), and obese Zucker rats with periodontitis (combination group). Periodontitis was ligature induced for 4 weeks in the periodontitis and combination groups, whereas the other groups were left unligated.Results: At 4 weeks, the gene expression for CRP, IL-6, and TNF-alpha in the liver and CRP and IL-6 in the WAT of combination groups was significantly higher than in each of the three groups. Serum TNF-alpha in the periodontitis and obesity groups was significantly higher than in the control group. Serum CRP and TNF-alpha in the combination group was significantly higher than in each of the three groups.Conclusion: Systemic low-grade inflammation after experimental periodontitis was associated with increased gene expression for hepatic levels of TNF-alpha and CRP and adipose tissue levels of IL-6 and CRP in the obese-rat model. J Periodontol 2010;81:520-526.