Defective macrophage function in a patient with common variable immunodeficiency.

Defective macrophage function in a patient with common variable immunodeficiency.
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常见变异型免疫缺陷患者的巨噬细胞功能缺陷。

DOI:
10.1056/nejm198209233071307
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发表时间:
1982
期刊:
The New England journal of medicine
影响因子:
--
通讯作者:
C. Zielinski
C. Zielinski
中科院分区:
--
文献类型:
--
作者:
M. Eibl;J. Mannhalter;G. Zlabinger;W. Mayr;G. Tilz;R. Ahmad;C. Zielinski

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常见变异型免疫缺陷的特点是导致无丙种球蛋白血症的不同免疫异常。1 在这种疾病中,已观察到不同水平的 B 细胞分化受损,2 并报道了与调节性 T 细胞异常相关的 B 细胞功能缺陷。3 4 5 6 尽管已知巨噬细胞在免疫反应的启动和调节中发挥重要作用,7 但尚未发现巨噬细胞功能缺陷与常见变异型免疫缺陷有关。在这项研究中,我们报道了一名患者,与我们大多数患有常见变异型免疫缺陷的患者一样,他对埃希氏菌的 T 细胞增殖反应减弱。 。 。
COMMON variable immunodeficiency is characterized by different immunologic abnormalities responsible for agammaglobulinemia.1 In this disease, impaired B-cell differentiation has been observed at different levels,2 and defects of B-cell function in connection with abnormalities of regulatory T cells have been reported.3 4 5 6 Even though macrophages are known to play an essential part in the initiation and regulation of the immune response,7 a defect in macrophage function has not been identified in connection with common variable immunodeficiency. In this study, we report on a patient who, like most of our patients with common variable immunodeficiency, had a depressed T-cell proliferative response to Escherichia . . .
与 T4 诱导 T 细胞功能丧失相关的免疫缺陷。
DOI: 10.1056/nejm198104023041403
发表时间: 1981
期刊: The New England journal of medicine
影响因子: --
作者:
Reinherz,EL;Geha,R;Wohl,ME;Morimoto,C;Rosen,FS;Schlossman,SF
通讯作者: Schlossman,SF
B 淋巴细胞对三硝基苯基共轭聚蔗糖的反应:对 T 淋巴细胞和 Ia 贴壁细胞的要求。
DOI: 10.1073/pnas.78.8.5113
发表时间: 1981
影响因子: 11.1
作者:
Letvin,NL;Benacerraf,B;Germain,RN
通讯作者: Germain,RN
通过单克隆抗体鉴定人单核细胞上的抗原。
DOI: --
发表时间: 1981
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Todd3rd,RF;Nadler,LM;Schlossman,SF
通讯作者: Schlossman,SF