Extent of underdiagnosis of familial hypercholesterolaemia in routine practice: prospective registry study
Extent of underdiagnosis of familial hypercholesterolaemia in routine practice: prospective registry study
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DOI：
10.1136/bmj.321.7254.148
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发表时间：
2000-07-15
影响因子：
--
通讯作者：
Humphries, SE
中科院分区：
文献类型：
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作者：
Neil, HAW;Hammond, T;Humphries, SE
在杂合子型家族性高胆固醇血症中，在60岁之前未经有效治疗的致死性或非致死性冠状动脉事件的累积风险在男性中至少为50%，在女性中约为30%。随着他汀类降脂药物的广泛使用，预后已得到显著改善。3估计这种情况的发生率约为1/500。我们的目的是确定诊断的家族性高胆固醇血症的患病率，并估计在常规临床实践中确定的预期病例的比例。
In heterozygous familial hypercholesterolaemia the cumulative risk of a fatal or non-fatal coronary event by the age of 60 without effective treatment is at least 50% in men and about 30% in women. 1 2 The prognosis has improved substantially with widespread use of statins for lipid lowering. 3 The estimated occurrence of the condition is about 1 in 500. 4 We aimed to determine the prevalence of diagnosed familial hypercholesterolaemia and to estimate the proportion of expected cases that are identified in routine clinical practice.