Natural oscillation frequencies in the two lateral prefrontal cortices induced by Transcranial Magnetic Stimulation
Natural oscillation frequencies in the two lateral prefrontal cortices induced by Transcranial Magnetic Stimulation
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DOI：
10.1016/j.neuroimage.2020.117655
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发表时间：
2021-02-15
期刊：
影响因子：
5.7
通讯作者：
Ambrosini, Ettore
中科院分区：
文献类型：
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作者：
Vallesi, Antonino;Del Felice, Alessandra;Ambrosini, Ettore
不同的皮质区域以不同的神经振荡节律模式对经颅磁刺激 (TMS) 做出反应。我们研究了 TMS 在左右同源背外侧前额皮质 (DLPFC) 中引起的固有频率以及相关的半球差异。在 12 名健康的年轻人中，在靠近 F3 和 F4 通道的不同模块中传递单脉冲 TMS，以靶向左右 DLPFC。刺激 PO3 附近的枕骨部位作为对照。对记录的脑电图数据进行了 TMS 相关的光谱扰动分析。所有刺激部位都观察到 θ 功率的广泛非特异性增加。然而，枕骨 TMS 诱导更大的 α 活动和 10.58 Hz 固有频率，而左侧和右侧 DLPFC 上的 TMS 导致类似的 β 带调制和分别为 18.77 和 18.5 Hz 的固有频率。特别是，右侧 DLPFC 与 TMS 相关的 β 活性特异性增加比左侧 DLPFC 更强。与左侧 DLPFC（或后部区域）上的 TMS 相比，当直接受到 TMS 刺激时，右侧 DLPFC 更具体地调整到其自然 β 频率，而左侧 DLPFC 更相似地增加其 β 活性，无论是直接刺激还是通过右侧同源刺激。这些结果对半球间前额叶相互作用的基础神经科学研究和临床应用产生了重要影响。
Different cortical regions respond with distinct rhythmic patterns of neural oscillations to Transcranial Magnetic Stimulation (TMS). We investigated natural frequencies induced by TMS in left and right homologous dorsolateral prefrontal cortices (DLPFC) and related hemispheric differences. In 12 healthy young adults, single-pulse TMS was delivered in different blocks close to F3 and F4 channels to target left and right DLPFC. An occipital site near PO3 was stimulated as control. TMS-related spectral perturbation analyses were performed on recorded EEG data. A widespread unspecific increase in theta power was observed for all stimulation sites. However, occipital TMS induced greater alpha activity and a 10.58 Hz natural frequency, while TMS over the left and right DLPFC resulted in similar beta band modulations and a natural frequency of 18.77 and 18.5 Hz, respectively. In particular, TMS-related specific increase in beta activity was stronger for the right than the left DLPFC. The right DLPFC is more specifically tuned to its natural beta frequency when it is directly stimulated by TMS than with TMS over the left counterpart (or a posterior region), while the left DLPFC increases its beta activity more similarly irrespective of whether it is directly stimulated or through right homologous stimulation. These results yield important implications for both basic neuroscience research on inter-hemispheric prefrontal interactions and clinical applications.