Mortality from cardiovascular disease more than 10 years after radiotherapy for breast cancer: nationwide cohort study of 90 000 Swedish women
Mortality from cardiovascular disease more than 10 years after radiotherapy for breast cancer: nationwide cohort study of 90 000 Swedish women
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DOI：
10.1136/bmj.326.7383.256
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发表时间：
2003-02-01
影响因子：
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通讯作者：
Ekbom, A
中科院分区：
文献类型：
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作者：
Darby, S;McGale, P;Ekbom, A
在乳腺癌的放射治疗过程中，心脏和主要血管经常受到一些照射，这可能会增加多年后的心血管死亡率。1-3当左乳房而不是右乳房受到影响时，对心脏的辐射剂量通常较高。因此，在肿瘤偏侧性（左或右乳房）可能与随后的心血管死亡率相关的情况下，可获得任何风险程度的间接证据。1 2对日本原子弹爆炸幸存者进行的研究表明，全身接受0-4戈伊的单次剂量，心血管疾病的风险与剂量有关，每戈瑞增加约14%。4
During radiotherapy for breast cancer there is often some irradiation of the heart and major blood vessels, which could increase cardiovascular mortality many years later. 1–3 The dose of radiation to the heart is generally higher when the left rather than the right breast is affected. Therefore, indirect evidence on the magnitude of any risk is available where the tumour laterality (left or right breast) can be linked to subsequent cardiovascular mortality. 1 2 Studies of the survivors of the atomic bombing of Japan who received single doses to the whole body of 0-4 Gy show that the cardiovascular disease risk is dose related and increases by about 14% per gray. 4