Associations between hepatitis C viremia and low serum triglyceride and cholesterol levels: A community-based study
Associations between hepatitis C viremia and low serum triglyceride and cholesterol levels: A community-based study
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DOI：
10.1016/j.jhep.2008.03.016
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发表时间：
2008-07-01
影响因子：
25.7
通讯作者：
Yu, Ming-Lung
中科院分区：
文献类型：
--
作者：
Dai, Chia-Yen;Chuang, Wan-Long;Yu, Ming-Lung
背景/目标：评估丙型肝炎病毒（HCV）感染者血清胆固醇和甘油三酯水平与病毒学状态的相关性。方法：我们进行了一项大规模的社区研究，在台湾南部B型肝炎病毒（HBV）和HCV感染流行区招募了11，239名居民。总计703（6.3%），1 536人（13.7%）、84（0.7%）和9，084 80.8%的受试者血清抗-HCV抗体阳性（抗-HCV）、肝炎B表面抗原（HBsAg）、抗-HCV和HBsAg均为阴性。经多因素Logistic回归分析，与血清胆固醇水平升高显著相关的独立因素为年龄大、女性、糖尿病、抗-HCV或HBsAg阴性、甘油三酯水平升高。与血清甘油三酯水平升高显著相关的独立因素为男性、糖尿病阳性、抗-HCV或HBsAg阴性、体重指数（BMI）较高和胆固醇水平升高。在642例抗-HCV阳性受试者中，通过标准化自动定性PCR检测HCV RNA，478例（74.5%）HCV RNA阳性。多因素Logistic回归分析显示，女性、血清甘油三酯水平升高、糖尿病和HCV RNA阴性是影响血清胆固醇水平升高的独立因素。与血清甘油三酯水平升高相关的独立因素是血清胆固醇水平升高、糖尿病阳性、BMI较高和HCV RNA阴性。结论：HCV病毒血症与血清胆固醇和甘油三酯水平降低有关，提示HCV本身可能对慢性HCV感染者的血脂水平起重要作用。(C)2008年欧洲肝脏研究协会。Elsevier B. V.出版，保留所有权利。
Background/Aims: To evaluate the association of virologic status with serum cholesterol and triglyceride levels in individuals with hepatitis C virus (HCV) infection.Methods: We conducted a large scale community-based study enrolling 11,239 residents in an area endemic for hepatitis B virus (HBV) and HCV infection in southern Taiwan. Overall, 703 (6.3%), 1,536 (13.7%), 84 (0.7%) and 9,084 (80.8%) subjects were sero-positive for anti-HCV antibody (anti-HCV), hepatitis B surface antigen (HBsAg), and both anti-HCV and HBsAg, and negative for anti-HCV and HBsAg, respectively.Results: By multivariate logistic analyses, the independent factors significantly associated with elevated serum cholesterol level were older age, female, negative for diabetes, anti-HCV or HBsAg and elevated triglyceride levels. The independent factors significantly associated with elevated serum triglyceride level were male, positive for diabetes, negative for anti-HCV or HBsAg, higher body mass index (BMI) and elevated cholesterol levels. Of 642 anti-HCV-positive subjects that have HCV RNA tested by standardized automated qualitative PCR assay, 478 (74.5%) were positive for HCV RNA. By multivariate logistic analyses, the independent factors associated with elevated serum cholesterol level were female, elevated serum triglyceride levels, negative for diabetes or HCV RNA. The independent factors associated with elevated serum triglyceride levels were elevated serum cholesterol levels, positive for diabetes, higher BMI and negative for HCV RNA. Diabetes, lower cholesterol and triglyceride levels were independent factors associated with positive HCV RNA.Conclusions: Based on the result of this large scale community study, HCV viremia appears to be associated with lower serum cholesterol and triglyceride levels which implies that HCV itself might play a significant role on serum lipid profile of patients with chronic HCV infection. (C) 2008 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.