Genetic deficiency of α1-PI in mice influences lung responses to bleomycin
Genetic deficiency of α1-PI in mice influences lung responses to bleomycin
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DOI：
10.1183/09031936.01.17304740
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发表时间：
2001-03-01
影响因子：
24.3
通讯作者：
Lungarella, G
中科院分区：
文献类型：
--
作者：
Cavarra, E;Martorana, PA;Lungarella, G
最近有人提出蛋白酶抑制剂调节肺的纤维化反应。本研究观察了博莱霉素在苍白小鼠（血清al-蛋白酶抑制剂缺乏，弹性蛋白酶抑制能力较低）和同类系C57 B1/6 J小鼠中引起的肺变化的发展。通过生物化学、形态学和形态计量学方法进行了调查，在两种菌株中，博来霉素治疗后21和72 h，肺显示与肺气肿相关的炎性细胞浸润灶。博莱霉素治疗后，纤维化逐渐发展。第14天，纤维化影响23.46+/-9.48%（平均值+/- SD）和40.62+/-13.33%（p
It has recently been suggested that proteinase inhibitors modulate the fibrotic response in the lung. This study investigated the development of bleomycin-induced pulmonary changes in pallid mice, deficient in serum al-proteinase inhibitor, and with a lower elastase inhibitory capacity, and in congenic C57Bl/6J mice.Male pallid and C57Bl/6J mice received a single intratracheal instillation of either saline or bleomycin. The investigation was carried out by means of biochemical, morphological and morphometrical methods.In both strains, 21 and 72 h after bleomycin, the lungs showed foci of inflammatory cell infiltration associated with emphysema. Fibrosis developed,vith time after bleomycin. At 14 days fibrosis affected 23.46+/-9.48% (mean +/- SD) and 40.62+/-13.33% (p