Frequency of antinuclear antibodies in healthy children and adolescents
Frequency of antinuclear antibodies in healthy children and adolescents
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DOI：
10.1177/000992280404300709
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发表时间：
2004-09-01
影响因子：
1.6
通讯作者：
Andrade, LEC
中科院分区：
文献类型：
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作者：
Hilário, MOE;Len, CA;Andrade, LEC
本文应用间接免疫荧光法（1117），以HEp-2细胞为底物，检测了214例6个月~ 20岁（平均8.7岁）健康儿童和青少年（108例女性，50.4%）及116例风湿性疾病患者血清中的抗核抗体（ANA）。27名健康儿童（12.6%）ANA检测呈阳性;性别间无差异，我们观察到5岁至10岁儿童ANA ≥ 1/80的频率较高的趋势。27例ANA阳性的健康儿童中有8例在36个月后复查，其中2例血清仍为阳性，但无1例发生风湿性疾病。116例患者中有42例（36.2%）存在ANA。在日常医疗实践中，ANA测定应仅在具有提示自身免疫性疾病的临床体征和症状的个体中需要。
Sera from 214 healthy children and adolescents (108 females [50.4%]) aged 6 months to 20 years (mean 8.7 years) and from 116 patients with rheumatic diseases were assayed for antinuclear antibody (ANA) by indirect immunofluorescence (1117) by using HEp-2 cells as substrate. Twenty-seven healthy children (12.6%) presented a positive ANA test; there was no difference between genders, and we observed a trend for higher frequency of ANA greater than or equal to 1/80 among children between 5 years and 10 years. Eight of the 27 healthy children with positive ANA test were reevaluated 36 months later, and none of them had developed any rheumatic disease, though the sera remained positive in 2 of them. ANA was present in 42/116 patients (36.2%). In daily medical practice ANA determination should be required only in individuals with clinical signs and symptoms suggestive of autoimmune disease.