INCREASED INCIDENCE OF STERILE ENDOPHTHALMITIS AFTER INTRAVITREAL TRIAMCINOLONE ACETONIDE IN SPRING 2006
INCREASED INCIDENCE OF STERILE ENDOPHTHALMITIS AFTER INTRAVITREAL TRIAMCINOLONE ACETONIDE IN SPRING 2006
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DOI：
10.1097/iae.0b013e31818eccb3
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发表时间：
2009-02-01
影响因子：
3.3
通讯作者：
Feuer, William
中科院分区：
文献类型：
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作者：
Stepien, Kimberly E.;Eaton, Alexander M.;Feuer, William
目的：比较2006年与2005年同期玻璃体内注射曲安奈德后6个月无菌性眼内炎的发生率，并确定改用不含防腐剂的曲安奈德后的发生率。方法：回顾性分析2005年3月至2005年8月、2006年3月至2006年8月、2006年3月至2006年8月以及2006年夏末至2007年2月期间在三家医院接受玻璃体内注射曲安奈德的患者发生无菌眼内炎的病例。结果：2005年3月至2005年8月，各医院无菌性眼内炎发生率为0%。2006年3月至2006年8月，各机构无菌性眼内炎发生率均有统计学意义的上升，为3.5% ~ 6.3% （P < 0.001）。随着改用不含防腐剂的曲安奈德，无菌眼内炎在接下来的6个月内在两个地点降至0%，在第三个机构降至2.5%（从5.5%）（P < 0.009）。结论：2006年玻璃体内注射曲安奈德后6个月内无菌性眼内炎发生率较2005年同期有统计学意义的增加。改用不含防腐剂的曲安奈德引起无菌眼内炎的频率与2005年相似。
Purpose: To compare the incidence of sterile endophthalmitis after intravitreal triamcinolone acetonide injections during a 6 month period in 2006 to the same period in 2005 and determine the incidence after switching to intravitreal preservative-free triamcinolone acetonide.Methods: Retrospective multicenter interventional case series in which patients receiving intravitreal triamcinolone acetonide at three institutions from March 2005 to August 2005 and from March 2006 to August 2006 and intravitreal preservative-free triamcinolone acetonide from late summer 2006 through February 2007 were reviewed for the development of sterile endophthalmitis.Results: From March 2005 to August 2005, the rate of sterile endophthalmitis was 0% at all institutions. From March 2006 to August 2006, a statistically significant increase in sterile endophthalmitis was seen at all institutions with frequencies of 3.5% to 6.3% (P < 0.001). With transition to preservative-free triamcinolone acetonide, sterile endophthalmitis over the next 6 months decreased to 0% at two sites and to 2.5% (from 5.5%) at the third institution (P < 0.009).Conclusions: A statistically significant increase in the rate of sterile endophthalmitis after intravitreal triamcinolone acetonide was seen in a 6 month period in 2006 when compared with the same period in 2005. Transition to preservative-free triamcinolone acetonide produced a frequency of sterile endophthalmitis similar to 2005.