Quantitative evaluation of electrical parameters influenced by blood flow rate with multiple-frequency measurement based on modified Hanai mixture formula
Quantitative evaluation of electrical parameters influenced by blood flow rate with multiple-frequency measurement based on modified Hanai mixture formula
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DOI：
10.1016/j.snb.2018.04.077
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发表时间：
2018-09
期刊：
影响因子：
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通讯作者：
Jianping Li;D. Kikuchi;A. Sapkota;M. Takei
中科院分区：
文献类型：
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作者：
Jianping Li;D. Kikuchi;A. Sapkota;M. Takei
通过多频电阻抗测量，明确了不同流速下猪流动血液的电参数（特征频率fc、形状因子α、零频率电阻R0和无限频率电阻R∞）的特性，以获得血流速度影响的物理解释。为了定量评估实验结果，从血流依赖因素（RBC（红细胞）方向、RBC 变形和 RBC 周围 EDL（双电层）厚度）的角度对静态胶体的传统 Hanai 混合公式进行了修改。将实验结果与改进的 Hanai 混合公式的理论评估进行了比较。该公式适用于评估流动血液的电参数特性，因为fc、α、R0和R∞的实验结果与理论结果之间的误差较小，仅为efc=3.4%、eα=19.3%、eR0=3.1%和eR1=1.7%。血流相关因素（红细胞方向、红细胞变形和 EDL 厚度）已被阐明，可解释流动血液电参数的变化。]
Characteristics of electrical parameters (characteristic frequencyfc, shape factorα,resistance at zero frequencyR0and resistance at infinite frequencyR∞) in swine flowing blood have been clarified under various flow rates by multiple-frequency electrical impedance measurement to obtain the physical interpretations for the influence of blood flow rate. In order to quantitatively evaluate the experimental results, the conventional Hanai mixture formula for static colloids has been modified from the viewpoint of blood flow-dependent factors which are RBC (red blood cell) orientation, RBC deformation and EDL (electrical double layer) thickness around RBCs. The experimental results are compared with the theoretical evaluations by the modified Hanai mixture formula. This formula is applicable to evaluate the characteristics of electrical parameters of flowing blood since the small errors forfc,α, R0andR∞between the experimental and theoretical results which are onlyefc= 3.4%,eα= 19.3%,eR0= 3.1% andeR1= 1.7%. Blood flow-dependent factors (RBC orientation, RBC deformation, and EDL thickness) are clarified to be accountable for the variation of electrical parameters of flowing blood.]