Misalignments of rest-activity rhythms in inpatients with schizophrenia
Misalignments of rest-activity rhythms in inpatients with schizophrenia
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DOI：
10.1111/j.1440-1819.2009.02047.x
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发表时间：
2010-01-01
影响因子：
11.9
通讯作者：
Yamada, Mitsuhiko
中科院分区：
文献类型：
--
作者：
Kodaka, Manami;Tanaka, Satoshi;Yamada, Mitsuhiko
目的：人类的休息-活动节奏通常与24小时的时间线索同步。很少有详细的研究调查了精神分裂症患者的休息-活动节律。本研究旨在探讨(i)精神分裂症患者的休息-活动节律，以及（ii）与其节律特征相关的因素。方法：我们只选择住院患者进行研究，因为住院患者的时间提示被认为比门诊患者的时间提示更规范。16名精神分裂症住院患者连续8天佩戴基于ActiTrac加速计的活动监测器（IM Systems Inc., Baltimore， USA）来测量他们的活动。我们使用chi 2周期图从活动数据中计算休息-活动节律，其中chi 2值幅度被视为规律性指标。我们进行了非参数测试，以确定与节律周期和模式相关的因素。结果：一半的参与者表现出延长的休息-活动周期，25%的参与者也表现出不规则的休息-活动模式，其定义为chi 2值幅度不足，即使他们明显处于24小时的时间提示下。休息-活动节律失调的参与者参加日间非药物治疗的频率较低，并且比节律正常的参与者接受了更多的抗焦虑/催眠药物。结论：通过优化药物和非药物治疗来改变休息-活动节律可改善精神分裂症患者的社会适应或生活质量。
Aims: Rest-activity rhythms of human beings generally synchronize to a 24-h time cue. Very few detailed research studies have examined rest-activity rhythms in patients with schizophrenia. The present study aimed to explore (i) rest-activity rhythms in patients with schizophrenia, and (ii) factors relevant to their rhythm characteristics.Methods: We selected only inpatients for this research, because the time cue for inpatients was considered more standardized than that of outpatients. Sixteen inpatients with schizophrenia wore an ActiTrac accelerometer-based activity monitor (IM Systems Inc., Baltimore, USA) for eight consecutive days to measure their activity. We used a chi 2 periodogram to compute rest-activity rhythms from the activity data, whereby the chi 2 value amplitude was regarded as an index of regularity. We conducted non-parametric tests to identify factors relevant to rhythm cycles and patterns.Results: Half of the participants exhibited prolonged rest-activity cycles, and 25% also had irregular rest-activity patterns defined by insufficient chi 2 value amplitude, even though they were clearly under a 24-h time cue. Participants with misaligned rest-activity rhythms had attended daytime non-medical treatment programs less frequently, and had received more anti-anxiety/hypnotic medications than those with proper rhythms.Conclusion: Changes in rest-activity rhythms by optimizing pharmacological and non-pharmacological treatment could improve social adjustment or quality of life in patients with schizophrenia.