CD160 signaling mediates PI3K-dependent survival and growth signals in chronic lymphocytic leukemia
CD160 signaling mediates PI3K-dependent survival and growth signals in chronic lymphocytic leukemia
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DOI：
10.1182/blood-2009-08-239483
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发表时间：
2010-04-15
期刊：
影响因子：
20.3
通讯作者：
Agrawal, Samir G.
中科院分区：
文献类型：
--
作者：
Liu, Feng-Ting;Giustiniani, Jerome;Agrawal, Samir G.
B细胞慢性淋巴细胞白血病（CLL）表达CD160，这是一种糖基磷脂酰肌醇相关受体，存在于正常的自然杀伤细胞（NK）和T细胞中，但不存在于B细胞中。CD160在正常淋巴细胞中是一种多功能分子，但其在CLL生物学中的作用尚不清楚。在体外，CLL细胞经历了快速的自发凋亡，CD160活化保护细胞免于平均细胞活力从67%增加到79% (P
B-cell chronic lymphocytic leukemia (CLL) expresses CD160, a glycosylphosphatidylinositol-linked receptor found on normal natural killer (NK) and T cells, but not B cells. CD160 is a multifunctional molecule in normal lymphocytes, but its role in CLL biology is unknown. In vitro, CLL cells undergo rapid spontaneous apoptosis, which CD160 activation protected against-mean cell viability increased from 67% to 79% (P