THE BASE EXCISION-REPAIR PATHWAY
THE BASE EXCISION-REPAIR PATHWAY
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DOI：
10.1016/s0968-0004(00)89086-6
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发表时间：
1995-10-01
影响因子：
13.8
通讯作者：
BJORAS, M
中科院分区：
文献类型：
--
作者：
SEEBERG, E;EIDE, L;BJORAS, M
碱基切除修复途径已经发展为保护细胞免受由水解、活性氧和修饰DNA碱基结构的其他细胞内代谢物诱导的内源性DNA损伤的有害影响。然而，碱基切除修复对于抵抗由电离辐射和强烷化剂产生的损伤也很重要，这与内源性因素诱导的损伤相似。
The base excision repair pathway has evolved to protect cells from the deleterious effects of endogenous DNA damage induced by hydrolysis, reactive oxygen species and other intracellular metabolites that modify DNA base structure. However, base excision repair is also important to resist lesions produced by ionizing radiation and strong alkylating agents, which are similar to those induced by endogenous factors.