Chromatin dynamics during differentiation of myeloid cells.
Chromatin dynamics during differentiation of myeloid cells.
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DOI：
10.1016/j.jmb.2014.08.015
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发表时间：
2015-02
影响因子：
5.6
通讯作者：
Jörg Schönheit;A. Leutz;F. Rosenbauer
中科院分区：
文献类型：
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作者：
Jörg Schönheit;A. Leutz;F. Rosenbauer
细胞分化需要调节蛋白与基本DNA和染色质紧密同步的时空相互作用。一个复杂的机制网络涉及谱系指导性转录因子的诱导，组蛋白修饰的安装或去除以及DNA甲基化模式的变化，局部协调三维染色质结构并决定细胞命运。造血干细胞的髓系成熟已成为研究细胞分化和谱系命运选择中染色质机制原理的有力模型。本文综述了近年来的知识，并就骨髓细胞的表观遗传动态如何影响发育、免疫激活和白血病转化结果提出了新的观点。
Cellular commitment to differentiation requires a tightly synchronized, spatial–temporal interaction of regulatory proteins with the basic DNA and chromatin. A complex network of mechanisms involving induction of lineage instructive transcription factors, installation or removal of histone modifications and changes in the DNA methylation pattern locally orchestrate the three-dimensional chromatin structure and determine cell fate. Maturation of myeloid lineages from hematopoietic stem cells has emerged as a powerful model to study those principles of chromatin mechanisms in cellular differentiation and lineage fate selection. This review summarizes recent knowledge and puts forward novel ideas on how dynamics in the epigenetic landscape of myeloid cells shape the development, immune activation and leukemic transformation outcome.