In Vitro Activity of Ceftaroline against Community-Associated Methicillin-Resistant, Vancomycin-Intermediate, Vancomycin-Resistant, and Daptomycin-Nonsusceptible Staphylococcus aureus Isolates
In Vitro Activity of Ceftaroline against Community-Associated Methicillin-Resistant, Vancomycin-Intermediate, Vancomycin-Resistant, and Daptomycin-Nonsusceptible Staphylococcus aureus Isolates
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DOI：
10.1128/aac.01516-09
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发表时间：
2010-07-01
影响因子：
4.9
通讯作者：
Johnson, Leonard
中科院分区：
文献类型：
--
作者：
Saravolatz, Louis;Pawlak, Joan;Johnson, Leonard
本研究评估了头孢洛林和5种对照药物对一系列金黄色葡萄球菌分离株的体外活性。头孢洛林对社区相关的耐甲氧西林沙门氏菌表现出有效的活性。金黄色葡萄球菌（CA-MRSA）分离株，并对万古霉素中间体S. aureus（VISA）、万古霉素耐药S.金黄色葡萄球菌（VRSA）、异源耐药VISA（hVISA）和达托霉素不敏感的S.金黄色葡萄球菌（DNSSA）分离株。头孢洛林可能是这些病原体引起的感染的杀菌治疗选择。
This study assessed the in vitro activities of ceftaroline and five comparator agents against a collection of Staphylococcus aureus isolates. Ceftaroline demonstrated potent activity against community-associated methicillin-resistant S. aureus (CA-MRSA) isolates and showed bactericidal activity against vancomycin-intermediate S. aureus (VISA), vancomycin-resistant S. aureus (VRSA), heteroresistant VISA (hVISA), and daptomycin-nonsusceptible S. aureus (DNSSA) isolates. Ceftaroline may represent a bactericidal treatment option for infections caused by these pathogens.