Biochemical characterization of human melanoma cell surfaces: dissection with monoclonal antibodies.
Biochemical characterization of human melanoma cell surfaces: dissection with monoclonal antibodies.
复制标题
人黑色素瘤细胞表面的生化特征：用单克隆抗体解剖。
DOI：
10.1073/pnas.77.12.7287
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发表时间：
1980
影响因子：
11.1
通讯作者：
Koprowski,H
中科院分区：
文献类型：
--
作者：
Mitchell,KF;Fuhrer,JP;Steplewski,Z;Koprowski,H
该报告描述了单克隆抗黑色素瘤抗体检测到的三种不同的人类黑色素瘤表面抗原的结构。一种抗原在所有黑色素瘤细胞和某些星形细胞瘤细胞上表达，但在测试的任何其他类型的正常细胞或肿瘤细胞上不表达，已被证明由我们相关的多肽链组成。在许多但不是所有黑色素瘤上表达的第二种抗原已被鉴定为 HLA-D 基因座的抗原产物，即 DR 抗原。第三种蛋白质抗原在任何测试的正常细胞上都没有发现，但出现在一些（但不是全部）各种来源的肿瘤上。
This report describes the structures of three distinct human melanoma surface antigens detected by monoclonal anti-melanoma antibodies. One antigen, expressed on all melanoma cells and on certain astrocytoma cells but not on any other kind of normal or tumor cell tested, has been shown to consist of our associated polypeptide chains. A second antigen expressed on many but not all melanomas has been identified as the antigenic product of the HLA-D locus, the DR antigen. A third protein antigen is not found on any normal cell tested but occurs on some, but not all, tumors of various origins.