A MALARIA MEROZOITE SURFACE PROTEIN (MSP1)-STRUCTURE, PROCESSING AND FUNCTION
A MALARIA MEROZOITE SURFACE PROTEIN (MSP1)-STRUCTURE, PROCESSING AND FUNCTION
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DOI：
10.1590/s0074-02761992000700004
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发表时间：
1992-01-01
影响因子：
2.8
通讯作者：
SHAI, S
中科院分区：
文献类型：
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作者：
HOLDER, AA;BLACKMAN, MJ;SHAI, S
裂殖子表面蛋白-1（MSP-1，也称为P195、PMMSA或MSA 1）是所有疟疾蛋白中研究最多的一种。这种蛋白质存在于所有被调查的疟疾物种中，对该基因的结构研究表明，该分子的某些部分是保守的。对恶性疟原虫的研究表明，该蛋白质在裂殖子表面以加工形式存在，这是大前体分子蛋白水解切割的结果。最近的研究已经确定了这些切割位点中的一些。在新的红细胞入侵期间，除了在环状阶段可以检测到的小的C-末端片段之外，大部分MSP 1分子从寄生虫表面脱落。对该片段的结构分析表明，它含有两个可能具有功能作用的生长因子样结构域。
Merozoite surface protein-1 (MSP-1, also referred to as P195, PMMSA or MSA 1) is one of the most studied of all malaria proteins. The protein is found in all malaria species investigated and structural studies on the gene indicate that parts of the molecule are well-conserved. Studies on Plasmodium falciparum have shown that the protein is in a processed form on the merozoite surface, a result of proteolytic cleavage of the large precursor molecule. Recent studies have identified some of these cleavage sites. During invasion of the new red cell most of the MSP1 molecule is shed from the parasite surface except for a small C-terminal fragment which can be detected in ring stages. Analysis of the structure of this fragment suggests that is contains two growth factor-like domains that may have a functional role.