Associations between tooth loss and mortality patterns in the Glasgow Alumni Cohort
Associations between tooth loss and mortality patterns in the Glasgow Alumni Cohort
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DOI：
10.1136/hrt.2006.097410
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发表时间：
2007-09-01
期刊：
影响因子：
5.7
通讯作者：
Gilthorpe, Mark S.
中科院分区：
文献类型：
--
作者：
Tu, Yu-Kang;Galobardes, Bruna;Gilthorpe, Mark S.
目的：使用数据从格拉斯哥校友队列调查口腔健康在年轻的成年人是否独立与以后的生活心血管疾病（CVD）和癌症mortality.Methods和结果：原始队列（n = 15 322），12 631例受试者通过国家卫生服务中心登记追踪。其中，9569名男性和2654名女性在基线时年龄为30岁或以下。在长达57年的随访中，有完整数据的受试者中发生了1432例死亡，包括509例死于心血管疾病和549例死于癌症。在调整了潜在的混杂因素后，没有发现缺牙数量与（作为连续变量）和全因死亡率（每颗额外缺失牙齿的风险比（HR）= 1.01; 95%置信区间（CI）1.00至1.02），CVD死亡率（HR = 1.01; 95% CI 0.99 - 1.03）或癌症死亡率（HR = 1.00; 95% CI 0.98 - 1.02）。当缺失牙齿的数量被视为一个分类变量时，有证据表明，与缺失牙齿少于5颗的学生相比，基线时缺失9颗或更多牙齿的学生患CVD的风险增加（HR = 1.35; 95%CI 1.03至1.77）。当使用分数多项式变换的牙齿缺失的数量，似乎是一个非线性的牙齿缺失和CVD mortality.Conclusions之间的关系：虽然一些证据被发现支持牙齿缺失和CVD死亡率之间的关系，这种关联的因果机制仍然不确定。
Objective: To use data from the Glasgow Alumni Cohort to investigate whether oral health in young adulthood is independently associated with later life cardiovascular disease ( CVD) and cancer mortality.Methods and results: Of the original cohort ( n = 15 322), 12 631 subjects were traced through the National Health Service Central Register. Of these, 9569 men and 2654 women were 30 years or younger at baseline. During up to 57 years of follow- up, 1432 deaths occurred among subjects with complete data, including 509 deaths from CVD and 549 from cancer. After adjusting for potential confounders, no substantial association was found between the number of missing teeth ( as a continuous variable) and all- cause mortality ( hazard ratio ( HR) for each extra missing tooth = 1.01; 95% confidence interval ( CI) 1.00 to 1.02), CVD mortality ( HR = 1.01; 95% CI 0.99 to 1.03) or cancer mortality ( HR = 1.00; 95% CI 0.98 to 1.02). When the number of missing teeth was treated as a categorical variable, there was evidence that students with nine or more missing teeth at baseline had an increased risk of CVD ( HR = 1.35; 95% CI 1.03 to 1.77) compared with those with fewer than five missing teeth. When the number of missing teeth was transformed using fractional polynomials, there seemed to be a non- linear relation between missing teeth and CVD mortality.Conclusions: Although some evidence was found to support the relation between tooth loss and CVD mortality, causal mechanisms underlying this association remain uncertain.