MUC1 mucin is expressed on human T-regulatory cells: Function in both co-stimulation and co-inhibition
MUC1 mucin is expressed on human T-regulatory cells: Function in both co-stimulation and co-inhibition
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DOI：
10.1016/j.cellimm.2011.10.012
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发表时间：
2012-01-01
影响因子：
4.3
通讯作者：
Agrawal, Babita
中科院分区：
文献类型：
--
作者：
Konowalchuk, Jeffrey D.;Agrawal, Babita
MUD粘蛋白是上皮细胞和上皮源性癌的重要蛋白质，也表达于活化的T细胞上，显示出正性和负性调节功能。目前尚不清楚MUC 1是否是T细胞的真正调节蛋白，以及什么条件导致MUC 1共刺激与共抑制。我们已经发现MUD在人体中的大多数T调节细胞（CD 4（+）/CD 25（+）/FoxP 3（+））上表达（>90%），并且CD 3/MUC 1共刺激导致T调节细胞数量增加。我们还发现，免疫调节功能依赖于辅助（CD 3（-））细胞的数量，与CD 3（-）细胞共抑制。
MUD mucin, an important protein of epithelial cells and epithelial-derived carcinomas, is also expressed on activated T cells, showing both positive and negative regulatory functions. It is currently unknown whether MUC1 is a true regulatory protein of T cells and what conditions lead to MUC1 co-stimulation versus co-inhibition. We have found that MUD is expressed on the majority of T-regulatory cells (CD4(+)/CD25(+)/FoxP3(+)) in humans (>90%) and that CD3/MUC1 co-stimulation leads to an increased number of T-regulatory cells. We also discovered that the immunoregulatory function is dependent upon the number of accessory (CD3(-)) cells present, with co-inhibition occurring with