Olfactory function after mild traumatic brain injury
Olfactory function after mild traumatic brain injury
复制标题
DOI：
10.1080/0269905021000010221
复制
发表时间：
2003-01-01
期刊：
影响因子：
1.9
通讯作者：
Twijnstra, A
中科院分区：
文献类型：
--
作者：
de Kruijk, JR;Leffers, P;Twijnstra, A
目的：探讨轻度颅脑外伤（MTBI）后嗅觉功能障碍的发生率。MTBI对嗅球或额叶皮质的损伤已有报道，但MTBI后的嗅觉功能障碍尚未有前瞻性研究。设计：纳入首次MTBI患者。在创伤后2周测量患者的嗅觉阈值（Olfacto-Labs(R)的hypomia Utility Kit）。嗅觉阈值、个体症状与S-100B和NSE浓度之间的关系通过多元线性回归分析进行了检验，并对年龄的影响进行了调整。结果：纳入的111例患者中有22%出现低通气，4%出现嗅觉缺失。2周时的阈值与急诊室症状的出现没有显著相关性，也与S-100B或NSE的早期浓度没有显著相关性。结论：虽然嗅觉功能障碍的患病率很高，但嗅觉功能障碍与MTBI的急性参数之间没有相关性。
Objective : The aim of this study was to determine the incidence of olfactory dysfunction after mild traumatic brain injury (MTBI). Damage to the olfactory bulbs or frontal cortex has been reported in MTBI, but olfactory dysfunction after MTBI has not been studied in a prospective way before.Design : Patients with first-time MTBI were included. Patients olfactory threshold values (Hyposmia Utility Kit by Olfacto-Labs(R)) were measured 2 weeks after the trauma. Associations between olfactory threshold values and individual symptoms and S-100B and NSE concentrations were examined, using multiple linear regression analysis, adjusting for the influence of age.Results : Twenty-two per cent of 111 included patients had hyposmia and 4% had anosmia. Thresholds at 2 weeks showed no significant associations with the presence of symptoms at the ER, nor with early concentrations of S-100B or NSE.Conclusions : Although a high prevalence of olfactory dysfunction was found, no correlation was found between olfactory dysfunction and acute parameters of MTBI.