Is docosahexaenoic acid more effective than eicosapentaenoic acid for increasing calcium bioavailability?
Is docosahexaenoic acid more effective than eicosapentaenoic acid for increasing calcium bioavailability?
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DOI：
10.1016/j.plefa.2005.08.001
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发表时间：
2005-11-01
影响因子：
3
通讯作者：
Schollum, LM
中科院分区：
文献类型：
--
作者：
Kruger, MC;Schollum, LM
实验动物和人体研究表明，长链多不饱和脂肪酸（LCPUFA）可以促进钙吸收，减少尿钙排泄，增加骨钙含量。本研究考察了月见草油、鱼油和金枪鱼油中LCPUFA对钙生物利用度的影响。饲喂半合成饲料6周后，测定生长雄性大鼠的钙吸收、骨矿物质密度（离体）、骨钙含量和骨生物力学性能。金枪鱼油组的钙吸收率、体外骨矿物质密度和骨钙含量均显著高于玉米油组。红细胞膜二十二碳六烯酸（DHA） （22:6n-3）含量与骨密度、骨钙含量呈显著相关。DHA比二十碳五烯酸（EPA）显著增加骨中钙的增加（20:5n-3）。(c) 2005 Elsevier Ltd版权所有。
Experimental animal and human studies have indicated that long chain polyunsaturated fatty acids (LCPUFA) may enhance calcium absorption, reduce urinary calcium excretion, and increase bone calcium content.In the present study, the effect of LCPUFA, as provided in evening primrose oil, fish and tuna oils, on calcium bioavailability was investigated. Growing male rats were fed a semi-synthetic diet for 6 weeks, after which calcium absorption, bone mineral density (ex vivo), bone calcium content, and bone biomechanics were measured. Calcium absorption, ex vivo bone mineral density, and bone calcium content were significantly higher in the animals fed tuna oil compared with those of a control group fed corn oil. Significant correlations were found between the docosahexaenoic acid (DHA) (22:6n-3) content of the red cell membranes and bone density and bone calcium content. DHA increased accretion of calcium in bone significantly more so than eicosapentaenoic acid (EPA) (20:5n-3). (c) 2005 Elsevier Ltd. All rights reserved.