Involvement of IL-10 and IL-4 in evasion strategies of Echinococcus granulosus to host immune response
Involvement of IL-10 and IL-4 in evasion strategies of Echinococcus granulosus to host immune response
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DOI：
10.1684/ecn.2009.0154
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发表时间：
2009-01-01
影响因子：
2.8
通讯作者：
Touil-Boukoffa, Chafia
中科院分区：
文献类型：
--
作者：
Amri, Manel;Mezioug, Dalila;Touil-Boukoffa, Chafia
人类包虫病是世界上主要的人畜共患病之一。在这项研究中，我们的目的是阐明寄生虫用于逃避和长期感染宿主的策略之一。我们希望为 IL-10/IL-4 参与这些机制提供进一步的免疫学证据。在这方面，我们研究了 IL-4 和 IL-10 对与患者 PBMC 共培养的原头节（PSC：寄生虫的幼虫形式）的影响。此外，我们使用 IL-4 和 IL-10 抗体来证实这种效果。我们的结果表明 IL-4 和 IL-10 减少了 PSC 的杀伤。这种减少与 PBMC 产生的 NO 减少相关。总之，本文报告的结果表明，IL-4/IL-10 会损害 Th1 保护反应，并使寄生虫在包虫患者体内存活。
Human echinococcosis is one of the world's major zoonotic infections. In this study, our aim is to clarify one of the strategies used by the parasite for evasion and prolonged infestation in the host. We wished to provide further immunological evidence for the involvement of IL-10/IL-4 in these mechanisms. In this regard, we investigated the effects of IL-4 and IL-10 on protoscoleces (PSC: the larval form of the parasite), co-cultured with patient PBMC. Furthermore, we used IL-4 and IL-10 antibodies to confirm this effect. Our results showed that IL-4 and IL-10 reduced PSC killing. This reduction correlates with an decrease in NO production by PBMC. In conclusion, the results reported here suggest that IL-4/IL-10 impairs the Th1 protective response and allows the parasite to survive in hydatid patients.