Jejunum-ileum circuit procedure improves glucose metabolism in diabetic rats independent of weight loss
Jejunum-ileum circuit procedure improves glucose metabolism in diabetic rats independent of weight loss
复制标题
空肠-回肠回路手术可改善糖尿病大鼠的葡萄糖代谢，与体重减轻无关
DOI：
10.1002/oby.21339
复制
发表时间：
2016-02-01
期刊：
影响因子：
6.9
通讯作者：
Hu, Sanyuan
中科院分区：
文献类型：
--
作者：
Wang, Yanmin;Zhang, Xiang;Hu, Sanyuan
ObjectiveTo introduce a lower-risk novel surgical procedure to achieve diabetes reversal along with associated hormonal changes.MethodsDiabetic rats were randomly assigned to jejunum-ileum circuit (JIC), sham-JIC, ileal interposition (IT), and sham-IT groups. The JIC group included two subgroups: short (JIC-S) and long (JIC-L), based on the length between anastomosis and Treitz ligament (L-AT). The body weight, food intake, blood glucose, glucose and insulin tolerance, and gut hormones were measured. The liver gene expression of glucose transporter 2 (GLUT2) and protein expression of glucose-6-phosphatase (G6P) and phosphoenolpyruvate carboxykinase (PKC) were also measured. Following a dye infusion, nutrient delivery was measured at termination day.ResultsCompared to sham-JIC group, JIC-S group did not reduce body weight or food intake but significantly improved glucose tolerance and insulin resistance. With fast chyme transit, JIC-S not only promoted the secretion of insulin, glucagon-like peptide 1, and peptide YY and decreased leptin, but also upregulated hepatic GLUT2 and downregulated hepatic G6P and PKC. JIC-L group, however, failed to achieve remission of diabetes.ConclusionJIC-S relieves diabetes independent of weight loss, as it promotes the secretion of anti-diabetic hormones and inhibits hepatic glucose production. The prolonging of L-AT, however, diminishes the hypoglycemic effect.
