Naloxone sensitive orphanin FQ-induced analgesia in mice.
Naloxone sensitive orphanin FQ-induced analgesia in mice.
复制标题
纳洛酮敏感孤啡肽 FQ 诱导的小鼠镇痛。
DOI：
10.1016/0014-2999(96)00578-x
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发表时间：
1996
影响因子：
5
通讯作者：
Pasternak,GW
中科院分区：
文献类型：
--
作者：
Rossi,GC;Leventhal,L;Pasternak,GW
孤啡肽（Orphanin FQ）是一种十七肽，与克隆的阿片受体家族的新成员具有非常高的亲和力，该家族在小鼠中产生痛觉过敏。除了在给予FQ后不久观察到的痛觉过敏外，我们现在描述延迟的镇痛反应。与阿片样物质引起的痛觉过敏不同，阿片样物质拮抗剂纳洛酮很容易逆转阿片样物质引起的镇痛，这意味着阿片样物质的作用机制。由于FQ对所有已知的传统阿片受体的亲和力都很差，而阿片类对FQ结合位点的亲和力也很低，因此FQ的镇痛作用可能是通过一种新的FQ受体亚型介导的。
Orphanin FQ, also known as nociceptin, is a heptadecapeptide with very high affinity for a novel member of the cloned opioid receptor family which produces hyperalgesia in mice. In addition to hyperalgesia, which is observed soon after administration of orphanin FQ, we now describe a delayed analgesic response. Unlike orphanin FQ-induced hyperalgesia, orphanin FQ-induced analgesia is readily reversed by the opioid antagonist naloxone, implying an opioid mechanism of action. In view of the very poor affinity of orphanin FQ for all the known traditional opioid receptors and the low affinity of opioids for the125I[Tyr14]orphanin FQ binding site, orphanin FQ-induced analgesia is probably mediated through a novel orphanin FQ receptor subtype.