Intestinal transit in dogs is accelerated by volume distension during fat-induced jejunal brake.
Intestinal transit in dogs is accelerated by volume distension during fat-induced jejunal brake.
复制标题
在脂肪引起的空肠制动过程中，体积膨胀会加速狗的肠道运输。
DOI：
10.1023/a:1005645405616
复制
发表时间：
2001
影响因子：
3.1
通讯作者：
Zhao,XT
中科院分区：
文献类型：
--
作者：
Lin,HC;Perdomo,OL;Zhao,XT
肠转运因容积扩张而加速，因营养负荷而减慢。我们假设容量扩张的加速效应可能会克服营养的减缓效应。为了验证这一假设，我们比较了肠道运输在五只狗配备了十二指肠和肠中瘘。用60 mM油酸盐灌注小肠的近端一半，而用缓冲液灌注小肠的远端一半（扩张）或不灌注（无扩张）。我们发现油酸盐使小肠传输减慢（标记物回收率从85.8 ± 5.3%降低到39.4 ± 7.5%）（P < 0.01），而容积扩张加速了小肠传输，使标记物回收率从无扩张时的39.4 ± 7.5%增加到扩张时的60.8 ± 6.3%（P < 0.05）。我们的结论是，肠运输加速体积扩张脂肪诱导的空肠制动。
Intestinal transit is accelerated by volume distension and slowed by nutrient load. We hypothesized that the accelerating effect of volume distension might overcome the slowing effect of nutrient. To test this hypothesis, we compared intestinal transit in five dogs equipped with duodenal and mid-intestinal fistulas. The proximal half of the small intestine was perfused with 60 mM oleate, while the distal half of the small intestine was either perfused with buffer (with distension) or left unperfused (without distension). We found that intestinal transit was slowed by oleate (with marker recovery reduced from 85.8 ± 5.3 to 39.4 ± 7.5%) (P < 0.01) and that volume distension accelerated intestinal transit so that marker recovery increased from 39.4 ± 7.5 without distension to 60.8 ± 6.3% with distension (P < 0.05). We concluded that intestinal transit is accelerated by volume distension during fat-induced jejunal brake.