Noradrenergic signaling in the amygdala contributes to the reconsolidation of fear memory - Treatment implications for PTSD
Noradrenergic signaling in the amygdala contributes to the reconsolidation of fear memory - Treatment implications for PTSD
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DOI：
10.1196/annals.1364.056
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发表时间：
2006-01-01
期刊：
影响因子：
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通讯作者：
LeDoux, Joseph E.
中科院分区：
文献类型：
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作者：
Debiec, Jacek;LeDoux, Joseph E.
由情感创伤引起的侵入性记忆是创伤后应激障碍（PTSD）的一个定义特征。现有的研究表明，在危及生命的事件中，去甲肾上腺素能活动的增加有助于加强或“过度巩固”创伤记忆。杏仁核外侧核（LA）对恐惧学习至关重要。使用经典的大鼠恐惧条件反射，我们最近已经证明，去甲肾上腺素能阻滞在LA后，通过检索重新激活的恐惧记忆，破坏记忆再巩固和持久损害恐惧记忆。这表明去甲肾上腺素能阻滞剂可能有助于减轻创伤性记忆，甚至是PTSD中巩固良好的旧记忆。
Intrusive memories resulting from an emotional trauma are a defining feature of posttraumatic stress disorder (PTSD). Existing studies demonstrate that an increase of noradrenergic activity during a life-threatening event contributes to strengthening or "overconsolidation" of the memory for trauma. The lateral nucleus of the amygdala (LA) is critical for fear learning. Using classical fear conditioning in rats, we have recently demonstrated that noradrenergic blockade in the LA following reactivation of fear memory by retrieval disrupts memory reconsolidation and lastingly impairs fear memory. This suggests that noradrenergic blockade may be useful in attenuating traumatic memories, even well-consolidated old memories, in PTSD.